Circadian rhythm and lithium response in bipolar disorder: Insights from actigraphy and NR1D1 polymorphism.

Lithium has long been used as a cornerstone mood stabilizer in the treatment of bipolar disorder (BD). However, reliable biomarkers that can predict which patients will respond better to lithium are still lacking. This study aims to evaluate the potential of NR1D1 gene SNP; rs2071427 and actigraphic measurements in predicting lithium response.

When the Expected Scenario Did Not Occur: A Novel Mutation Resembling Neuromyelitis Optica Spectrum Disorder.

Mitochondrial complex I transfers electrons from NADH (nicotinamide adenine dinucleotide) to ubiquinone, facilitating ATP synthesis via a proton gradient. Complex I defects are common among the mitochondrial diseases, especially in childhood. , located in complex I's transmembrane domain, is not directly involved in catalytic activity, but the mutations are associated with Leigh syndrome and complex I defects.

Dichlorination of olefins with trichloroisocyanuric acid (TCCA) and tetrabutylammonium chloride (TBACl).

Herein, a new metal-free, molecular chlorine-free, environmentally friendly, atom-economical, short time, inexpensive and simple operation method with mild reaction conditions for chlorination of alkenes, cyclic alkenes, ,-unsaturated carbonyl compounds, heteroaromatics, and natural products was reported with up to 96% yields using trichloroisocyanuric acid (TCCA) as the electrophilic chlorine source and TBACl as the nucleophilic chlorine source. It was demonstrated with bicyclic alkene benzonorbornadiene that regioselective chlorobromination and dibromination reactions can be carried out through TCCA/TBABr redox reactions, where TCCA acts as an oxidant in the presence of TBABr. The structures of the redox products were confirmed as a result of control experiments conducted with the newly presented DBI/TBACl and DBI/TBABr halogenation pairs.

Patient-derived cornea organoid model to study metabolomic characterization of rare disease: aniridia-associated keratopathy.

Background: Aniridia is a rare panocular disease caused by gene mutation in the PAX6, which is essential for eye development. Aniridia is inherited in an autosomal dominant manner, but its phenotype can vary significantly among individuals with the same mutation. Animal models, such as drosophila, zebrafish, and rodents, have been used to study aniridia through Pax6 deletions.

Robot-assisted Kidney Transplantation: The 8-year European Experience.

Background And Objective: Evidence regarding perioperative results and long-term functional outcomes of robotic-assisted kidney transplantation (RAKT) is limited. We evaluated perioperative surgical results and long-term functional outcomes of RAKT in patients receiving kidney transplants from living donors.

Methods: This retrospective analysis is based on a prospective multicenter cohort study conducted from July 2015 to October 2023 across ten European centers.

Examination of ChatGPT's Performance as a Data Analysis Tool.

This study examines the performance of ChatGPT, developed by OpenAI and widely used as an AI-based conversational tool, as a data analysis tool through exploratory factor analysis (EFA). To this end, simulated data were generated under various data conditions, including normal distribution, response category, sample size, test length, factor loading, and measurement models. The generated data were analyzed using ChatGPT-4o twice with a 1-week interval under the same prompt, and the results were compared with those obtained using R code.

Otomycosis risk after non-suppurative middle ear surgery.

Objectives: The aim of this study was to investigate the risk factors that may cause postoperative otomycosis in patients undergoing Chronic Nonsuppurative Otitis Media (CNSOM) surgery.

Methods: In this retrospective study, 409 out of 523 patients met the inclusion criteria. 44 patients diagnosed with otomycosis CNSOM were analyzed.

Morphological Features of the Pecten Oculi in the Common Kestrel (Falco tinnunculus).

This study aimed to investigate the macroscopic, light microscopic (LM) and scanning electron microscopic (SEM) characteristics of the pecten oculi in common kestrels (Falco tinnunculus). A total of six eyeballs from three common kestrels were used as the study material. The examination revealed that the bulbus oculi was spherical in shape and its diameter exceeded the axial-global length.

Design and Development of a Self-Report Competence Scale for The Assessment of Prehospital Health Professionals' Competence in Response to Radiological Events.

Objectives: The objective of this study was to develop a self-report scale for the assessment of the competence of pre-hospital health professionals in responding to radiological incidents.

Methods: Based on the findings of a systematic review analyzing the literature, the instrument followed the processes of item generation, expert opinion, language control, pilot study, and field testing.

Results: In the exploratory factor analysis, 48 items were excluded on the grounds of insufficient common variance (>0.

The impact of high-intensity interval training on insulin resistance, oxidative stress, and muscle function in a PCOS rat model.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders . This study aimed to investigate the effects of high-intensity interval training (HIIT) on insulin resistance, oxidative stress, soleus muscle function, and myokine levels in a PCOS rat model. Female rats were assigned to four groups: Control, PCOS, PCOS+Exercise, and Exercise (n=15 each).

Post-Traumatic Symptoms and Sleep Problems in Children and Adolescents after Twin Earthquakes in Turkey.

Objectives: Earthquakes cause great destruction due to their suddenness and intensity. Although all people are affected by earthquakes, children are among those most affected. Every year, millions of children and young people are exposed to many natural disasters and are affected differently.

Integration of Optical Coherence Tomography Images and Real-Life Clinical Data for Deep Learning Modeling: A Unified Approach in Prognostication of Diabetic Macular Edema.

The primary ocular effect of diabetes is diabetic retinopathy (DR), which is associated with diabetic microangiopathy. Diabetic macular edema (DME) can cause vision loss for people with DR. For this reason, deciding on the appropriate treatment and follow-up has a critical role in terms of curing the disease.

Determination of HLA Tissue Type According to the Etiology of Patients with Chronic Renal Failure.

Objective: Chronic kidney disease (CKD) is a prominent public health concern, is defined as functional and structural damage to the kidneys. This study aims to investigate the association between human leukocyte antigen (HLA) alleles individuals with CKD and the different etiological subgroups of diesease.

Methods: Genomic DNA was obtained from peripheral blood samples of 1,079 patients with retrospective CKD and 1,111 healthy control individuals.

Assessment of atmospheric volatile organic compounds at two crude oil production plants in Southeastern Türkiye.

Ambient Volatile Organic Compounds (VOCs) were investigated to determine their characteristics, Ozone Formation Potentials (OFPs), and health risks in two crude oil production plants (Nusaybin and Egil plants) in southeastern Türkiye. Benzene, toluene, ethylbenzene, m + p xylene, o xylene, and 1,3,5-trimethylbenzene were measured at eight passive sampling points in each plant. Samples were analyzed using gas chromatography coupled with a flame ionization detector and a thermal desorption.

Splenic flexure mobilization: does body topography matter?

Background: Splenic flexure mobilization can be technically challenging, and its oncological benefits remain uncertain. This study aims to explore the relationship between patient and clinical characteristics and splenic flexure mobilization time as well as the implications of prolonged splenic flexure mobilization duration.

Methods: This retrospective cohort study includes 105 patients who underwent laparoscopic distal colorectal cancer surgery between 2013 and 2018.

Effect of Estimated Individual Vitreous Volume on Intraocular Pressure Spikes After Intravitreal Anti-Vascular Endothelial Growth Factors Injection.

Introduction: The present study aimed to evaluate the effect of estimated individual vitreous volume on intraocular pressure (IOP) spikes after intravitreal anti-vascular endothelial growth factor (VEGF) injections (IVI).

Methods: Vitreous volumes (VV) of eyes were calculated using an axial length (AL) based formula AL3 x (π/6) x 0.76+0.

Perception of Internalized Stigma in Parents of Children With Autism Spectrum Disorder: Investigating the Effects of Depression, Anxiety, and Family Functioning.

Introduction Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that impacts communication, behavior, and social interaction. It is well-documented that parents of children with ASD often experience psychiatric conditions like anxiety and depression. Nevertheless, research on the perception of internalized stigma, family functioning, and their interconnections is scarce.

Large Language Model Ability to Translate CT and MRI Free-Text Radiology Reports Into Multiple Languages.

Background High-quality translations of radiology reports are essential for optimal patient care. Because of limited availability of human translators with medical expertise, large language models (LLMs) are a promising solution, but their ability to translate radiology reports remains largely unexplored. Purpose To evaluate the accuracy and quality of various LLMs in translating radiology reports across high-resource languages (English, Italian, French, German, and Chinese) and low-resource languages (Swedish, Turkish, Russian, Greek, and Thai).

Lateralization outcomes of bilateral inferior petrosal sinus sampling: desmopressin vs CRH.

Purpose: Bilateral inferior petrosal sinus sampling (BIPSS) is the gold standard for localizing ACTH-dependent Cushing's syndrome (CS). While corticotropin-releasing hormone (CRH) was initially used for stimulation, desmopressin has become a common alternative. This research evaluates desmopressin's effectiveness in lateralizing Cushing's disease (CD) during BIPSS compared to CRH stimulation.

The Role of Social Support in Enhancing Life Satisfaction Among Syrian Refugees in Türkiye During the COVID-19 Pandemic.

Purpose: This study investigates the role of perceived social support from family and friends in enhancing life satisfaction among Syrian refugees in Türkiye during the COVID-19 pandemic.

Materials And Methods: A cross-sectional survey was conducted among 636 Syrian refugees residing in Istanbul and Hatay provinces. The study used the Multidimensional Perceived Social Support Scale, the COVID-19 State Anxiety Sources Scale, and the Satisfaction With Life Scale.

The role of eosinophil counts and megakaryocyte nuclei for distinction of acute and chronic immune thrombocytopenic purpura.

Objective: Immune thrombocytopenic purpura (ITP), the most common cause of thrombocytopenia, is clinically classified as acute and chronic. This study aimed to distinguish between acute/chronic ITP parameters examined at diagnosis via complete blood count (CBC), peripheral blood (PB) and bone marrow aspirate (BMA) smears. It would also contribute to early treatment options, cost-effective policies, and the life quality of patients.

Evolution of Diagnostic Medical Physics Enterprise.

The roles and responsibilities of radiation safety officers (RSO), medical health physicists (MHP) and diagnostic medical physicists (DMP) have evolved significantly over the past 20 years. With the availability of enterprise software systems and aggregated data platforms for various radiologic healthcare systems, the roles of these professions are expanding beyond their original scopes in managing the Radioactive Materials License (RSO, MHP) and Machine Specific Physics Testing (DMP). Workers in medical radiation safety are transitioning from siloed workers working within their specific disciplines as new emerging technology and clinical care require these roles to evolve.

Porcupine inhibitors LGK-974 and ETC-159 inhibit Wnt/β-catenin signaling and result in inhibition of the fibrosis.

Objectives: We evaluated potential therapeutic efficacy of LGK-974 and ETC-159 in fibrotic scleroderma cells.

Methods: Primary scleroderma dermal fibroblast cells of mouse origin (SSc fibroblasts) and primary fibrotic lung fibroblast cells of human origin (CCL-191) were used in this study. PORCN inhibitors LGK-974 (S7143, 1 μM; Selleckchem, USA) and ETC-159 (S7143, 10 μM; Selleckchem, USA) were used.