From Prediction to Precision: Explainable AI-Driven Insights for Targeted Treatment in Equine Colic.

Colic is a leading cause of mortality in horses, demanding precise and timely interventions. This study integrates machine learning and explainable artificial intelligence (XAI) to predict survival outcomes in horses with colic, using clinical, procedural, and diagnostic data. Random forest and XGBoost emerged as top-performing models, achieving F1 scores of 85.

Overcoming low status or maintaining high status? A multinational examination of the association between socioeconomic status and honour.

We examined the relationship between socioeconomic status (SES) and endorsement of honour. We studied the SES-honour link in 5 studies (N = 13,635) with participants recruited in different world regions (the Mediterranean and MENA, East Asian, South-East Asian, and Anglo-Western regions) using measures that tap into various different facets of honour. Findings from these studies revealed that individuals who subjectively perceived themselves as belonging to a higher (vs.

Food Neophobia and Two Facets of Orthorexia Among Women: Cross-Sectional Study.

The purpose of this study was to investigate the link between food neophobia and two dimensions of orthorexia in women. This cross-sectional study of 985 women aged 18 years and over was conducted using face-to-face questionnaires. Women who had a disability, had a chronic disease, or were pregnant or breastfeeding were excluded.

Comprehensive evaluation of the toxicological effects of commonly encountered synthetic cathinones using in silico methods.

Synthetic cathinones (SCs), a group of new psychoactive substances (NPS), are designer molecules with hallucinogenic and psychostimulatory effects. Although the structural similarities of SCs to amphetamines suggest that they may have similar toxicity profiles to those of amphetamine congeners, little is known about SCs from a toxicological point of view. In the present study, the toxicity profiles of commonly encountered SCs ( = 65), listed in the 2020 Report of the United Nations Office on Drugs and Crime (UNODC), were evaluated using in silico methods.

Protective effect of essential oil inhalation on neuromodulators regulating the sleep/wake cycle in rats with total sleep deprivation.

Objectives: This study aimed to investigate the potential effects of different doses of essential oil (Lavender EO) administered by inhalation on sleep latency and neuromodulators regulating the sleep/wake cycle in rats with total sleep deprivation (TSD).

Materials And Methods: Forty-eight male Sprague-Dawley rats were divided into five groups: Control, Alprazolam (ALP, 0.25 mg/kg given intraperitoneally), L1 (Lavender EO, 0.

Dynamine 3 as a Diagnostic and Prognostic Biomarker in Pancreatic Cancer: Implications for Early Detection and Targeted Therapy.

Background: Dynamins are defined as a group of molecules with GTPase activity that play a role in the formation of endocytic vesicles and Golgi apparatus. Among them, DNM3 has gained recognition in oncology for its tumor suppressor role. Based on this, the aim of this study is to investigate the effects of the DNM3 gene in patients diagnosed with pancreatic cancer using bioinformatics databases.

Assessment of diabetes-specific eating disorder risk in adult patients with diabetes.

Purpose: Adults with type 1 diabetes (T1D) are reported to be at higher risk for clinical eating disorders (ED) and other disordered eating behaviors (DEB) than their peers without diabetes. On the other hand, there is insufficient data on DEB in adults with type 2 diabetes (T2D). Our study aimed to investigate the prevalence of DEB in patients with T1D and T2D on intensive insulin therapy followed in our outpatient clinic.

A widespread and ancient bacterial machinery assembles cytochrome OmcS nanowires essential for extracellular electron transfer.

Microbial extracellular electron transfer (EET) drives various globally important environmental phenomena and has biotechnology applications. Diverse prokaryotes have been proposed to perform EET via surface-displayed "nanowires" composed of multi-heme cytochromes. However, the mechanism that enables only a few cytochromes to polymerize into nanowires is unclear.

2-Phenylbenzothiazoles featuring heteroaryl sulfonamide end-capping substructures as developable mPGES-1 inhibitors.

The inhibition of human microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is a promising therapeutic modality for developing next-generation anti-inflammatory medications. In this study, we present novel 2-phenylbenzothiazole derivatives featuring heteroaryl sulfonamide end-capping substructures as inhibitors of human mPGES-1, with IC values in the range of 0.72-3.

Mini-crush or Nano-crush Stenting Technique for Complex Coronary Bifurcation Lesions: The Multicenter MINANO Registry.

Background: This multicenter study aimed to retrospectively evaluate the mid-term clinical outcomes of mini-crush (MCT) and nano-crush (NCT) techniques in patients with complex bifurcation lesions (CBLs).

Methods: The study comprised 431 patients [male: 318 (73.8%), mean age: 60.

Can serum orexin levels be used as a marker in childhood epilepsy?

Objective: Epilepsy is one of the most common neurological diseases in the pediatric population. Orexins are excitatory peptides and associated with energy homeostasis, eating and drinking behaviors, sleep regulation, sleep-wake periods, analgesia, and cognitive activities such as attention, learning, and memory. The aim of this study was to reveal the relationship between plasma orexin levels and seizures in pediatric epilepsy patients with seizures, epilepsy patients in remission, and healthy control group with similar demographic characteristics.

Investigation of the effects of silymarin and vitamin C on kidney damage and aquaporin-2 downregulation in lithium-induced nephrogenic diabetes insipidus in rats.

Although lithium (LIT) therapy is key in managing bipolar disorder long-term, prolonged use significantly contributes to acquired Nephrogenic Diabetes Insipidus (NDI). This study examined whether combining Silymarin (SIL) with Vitamin C (Vit C) enhances protection against lithium-induced nephrotoxicity in rats, comparing their individual antioxidant effects as well. Rats subjected to Li exposure were provided with a standard commercial diet supplemented with 80 mmol LiCl per kilogram for 28 days.

NORSE secondary to anti-GAD65 antibody-positive encephalitis treated with novel adjunctive rapid titration VNS protocol.

New Onset Refractory Status Epilepticus (NORSE) is a rare and severe condition characterized by refractory seizures in individuals without a prior history of epilepsy. This case report describes a 37-year-old woman diagnosed with anti-glutamic acid decarboxylase 65 (anti-GAD65) antibody-positive encephalitis-related NORSE. Her seizures were refractory to multiple interventions, including anti-seizure medications, anesthetics, immunotherapies, a ketogenic diet, and electroconvulsive therapy.

Influence of Formulation Composition on the Characteristic Properties of 5-fluorouracil-loaded Liposomes.

Objectives: Variations in the types and quantities of excipients used to prepare liposomes can affect the physicochemical properties of liposome formulations. This study aimed to provide information about the design and fabrication of 5-fluorouracil (5-FU)-loaded liposome formulations using different lipid and cholesterol (CHOL) derivatives.

Materials And Methods: Passive loading via a small-volume incubation method was used to prepare liposomes.

Large Unstained Cells (LUC): A Novel Predictor of CDK4/6 Inhibitor Outcomes in HR+ HER2-Negative Metastatic Breast Cancer.

: Although CDK4/6 inhibitors combined with endocrine therapies have improved outcomes in HR+ HER2-negative metastatic breast cancer, predictive biomarkers for treatment response and adverse effects remain limited. This study assessed the prognostic and predictive value of large unstained cells (LUC), a subset of white blood cells that may reflect immune status or treatment response. : A retrospective analysis of 210 patients with HR+ HER2-negative metastatic breast cancer treated with CDK 4/6 inhibitors between 2021 and 2024 was conducted.

Maternal Perception and Childhood Overweight: Examining Parenting Styles and Eating Behaviors Among Preschoolers: A Cross-Sectional Study from Samsun, Türkiye.

Background: Accurate maternal perceptions of children's weight status are crucial for early childhood obesity prevention, with evidence suggesting that maternal misperception may delay timely interventions. This study investigated the accuracy of maternal perceptions of child weight and examined associations with parenting styles and children's eating behaviors and demographic factors among preschool-aged children in Samsun, Türkiye.

Methods: This cross-sectional study included 318 mother-child pairs recruited from preschools in socio-economically diverse areas of Samsun.

Evaluation of as a Feed Additive in Low-Protein Diets of Broilers.

is a natural antioxidant product that has the ability to improve the performance of poultry. Therefore, the present study aimed to evaluate the effect of using as a feed additive in broiler diets. A total of 252 daily male Ross 308 chicks were randomly assigned to six groups.

The effect of dual-task training in older adults with total hip arthroplasty: a randomized controlled trial.

Background: No other study has addressed the effectiveness of dual-task training in the postoperative period of total hip arthroplasty (THA). This study investigated the efficacy of dual-task training in older adults with THA.

Methods: Patients were randomized into the control group (CG) (n = 14) and intervention group (IG) (n = 14).

The association between HALP score and survival in patients treated with immune checkpoint inhibitors.

Background: The hemoglobin, albumin, lymphocyte, and platelet (HALP) score could be a prognostic biomarker in patients with cancer as a reflector of nutritional and inflammatory status, although the data is limited in patients treated with immune-checkpoint inhibitors (ICIs). Therefore, we sought to investigate the relationship between HALP score and survival in ICI-treated patients.

Methods: We included adult patients with advanced cancer treated with ICIs between June 2016 and January 2024.

The role of irisin and cytokines in the etiology of parotid tumors.

This study explores the role of irisin and interleukins in parotid tumors by determining the tissue staining intensity of irisin, the salivary and plasma levels of irisin, and the plasma levels of IL-4, IL-6, IL-10 and TNF-alpha in individuals with parotid tumors. Forty-eight patients and forty healthy individuals were included to the study and allocated into four group. Benign Group I (pleomorphic adenoma), Group II (Warthin's tumor), Group III (mucoepidermoid carcinoma) and Group IV (benign parotid control group, healthy control group).

Awareness and Knowledge of Endocrine-Disrupting Chemicals Among Pregnant Women and New Mothers: A Cross-Sectional Survey Study.

Background/objectives: Endocrine-disrupting chemicals (EDCs) are exogenous substances that interfere with hormone regulation, leading to adverse health outcomes. Despite the wide use of EDCs in daily products like plastics, personal care items, and food packaging, public awareness remains low. Pregnant women and new mothers are particularly vulnerable, as exposure to EDCs during early life stages can have long-term health impacts.

Osteopontin Levels in Maternal Serum, Cord Blood, and Breast Milk According to Gestational Diabetes Mellitus: A Case-Control Study.

Background/objectives: The prevalence of gestational diabetes mellitus (GDM) is increasing, and GDM poses health risks for both mothers and newborns. This study investigated the association between GDM and two biomarkers, osteopontin (OPN) and betatrophin (ANGPTL8).

Methods: This study involved face-to-face interviews with 165 participants-81 in the GDM group and 84 in the control group-to gather maternal-newborn data.

Drug Safety During Breastfeeding: A Comparative Analysis of FDA Adverse Event Reports and LactMed.

Background/objectives: While breastfeeding is highly recommended, breastfed infants may be exposed to drugs by milk due to maternal pharmacotherapy, resulting in a risk of adverse drug events (ADE) or reactions (ADRs). The U.S.

Evaluation of the effects of favipiravir (T-705) on the lung tissue of healty rats: An experimental study.

Favipiravir, a broad-spectrum RNA-dependent RNA polymerase inhibitor widely used during the COVID-19 pandemic, effectively reduces viral load but has been linked to inflammatory changes in tissues such as the liver and kidneys. High-dose and prolonged use of favipiravir for COVID-19 raises concerns about its potential toxic effects on the lungs, particularly in patients with pre-existing pulmonary conditions. This study investigated favipiravir's effects on lung tissue in healthy rats.