Development and validation of a dynamic prognostic nomogram for conditional survival in hepatocellular carcinoma: an analysis from the Korea Liver Cancer Registry.

Compared to overall survival, conditional survival is a more relevant measure of prognosis in surviving patients over time. This study developed and validated a nomogram-based dynamic prognostic model to predict the conditional survival estimates of patients with hepatocellular carcinoma (HCC) through an analysis of a nationwide cancer registry. This retrospective cohort study included 2492 patients with HCC registered in the Korea Liver Cancer Registry.

Optimization of Injection Molding Process for High-Strength and Lightweight Back Rest of Firefighters Using Carbon Fiber Composites of Long Fiber Thermoplastic with Flame Retardants.

This study focuses on reducing the weight of oxygen respirators in firefighters' personal protective equipment (PPE), which currently accounts for about 56% of the total weight. The heavy PPE, weighing between 20 and 25 kg, restricts movement and can lead to musculoskeletal injuries. To address this, the study investigates using a carbon fiber-reinforced composite for the backrest of the oxygen respirator to reduce weight while maintaining strength.

Microbiota associated with caries and apical periodontitis: A next-generation sequencing study.

Aim: This study investigated the correlation between microbiota of caries-free enamel and caries-affected dentine biofilms and that of root canals with primary apical periodontitis, by using an Illumina MiSeq platform.

Methodology: Biofilm from caries-free enamel surface (Biofilm-C) or caries-affected dentine (Biofilm-E) and root canal paper point samples (Canal) were collected from 31 teeth with primary apical periodontitis. Microbial composition was analysed by amplicon sequencing that targeted the V3-V4 region of 16S rRNA gene.

Association of Co-Curricular Activities to ACPE Standard #3 Elements by Student-Reported Competencies.

Objective: To assess the influence of required co-curricular activities on Accreditation Council of Pharmacy Education (ACPE) Standards 2016: Standard #3 Elements-Approach to Practice and Care competencies using year-end student surveys.

Methods: Year-end surveys of P1-P4 students compared student self-assessments of their own aptitude for each Advancement of Pharmacy Education (CAPE) 2013 outcomes in ACPE Standard #3 from a three-year period where co-curricular activities were voluntary (volunteer period) with three years where a unique co-curricular activity was required each semester without academic credit (required period). A total of 294 unique co-curricular activities were offered through the required period.

Evaluation of SALT score severity in correlation with trichoscopic findings in alopecia areata: a study of 303 patients.

Background: Alopecia areata (AA) is a common autoimmune non-scarring type of hair loss characterized by round patches on the scalp or body. AA is the second most common form of hair loss after male-pattern baldness in men, and female-pattern baldness in women.

Aim Of The Study: This study aims to examine the correlation between trichoscopic patterns and AA severity, evaluated by the Severity of Alopecia Tool (SALT) score, and to analyze the impact of demographic and clinical factors on treatment outcomes.

A systematic review of fall prevention interventions in frail older adults.

Frail older adults are vulnerable to falls. This review aimed to identify the characteristics of fall prevention interventions and assess their effects on fall-related outcomes in the population. Six databases were searched using keywords such as frailty, older adults, fall prevention or management, and education.

Patient experiences in multidisciplinary care for persistent somatic symptoms across four European countries: a cross-sectional comparison.

Objectives: The aim of this study is to explore patients with persistent somatic symptoms and functional disorders' (PSS/FD) experiences of and preferences for multidisciplinary care across Europe. A further aim is to compare the experiences of and preferences for multidisciplinary care of patients to those of healthcare professionals (HCPs) in the Netherlands.

Design: Cross-sectional online survey.

Pathways to strengthening the epidemic intelligence workforce.

The evolving landscape of public health surveillance demands a proficient and diverse workforce adept in data science and analysis. This report summarises discussions from the third session of the WHO Pandemic and Epidemic Intelligence Innovation Forum, focusing on workforce readiness and technological advancements in epidemic intelligence. The forum emphasizes the necessity of multidisciplinary surveillance teams equipped with advanced data skills.

Cyclodextrin modified biocompatible Chitosan-Cinnamaldehyde Schiff base hydrogels: Their antibacterial, antioxidant, and drug delivery potential.

Chitosan (CS)-based hydrogels are promising platforms for drug delivery owing to their biocompatibility, biodegradability, and functional versatility. However, pure CS Schiff base hydrogels lack mechanical strength and rely on toxic cross-linkers, necessitating bio-safe alternatives viz. Cinnamaldehyde (CA).

Racial/Ethnic and Immigrant Disparities in the Relationship Between Insurance and Cost-Related Unmet Health Needs in Adolescence.

Objective: Addressing cost-related unmet health needs is critical to ensuring positive health outcomes in adolescence. Promoting insurance coverage is a common strategy for reducing cost-related unmet health needs, but public insurance programs and private insurance differ in the number and types of no-cost services provided, and groups with higher average poverty rates such as immigrants and racial and ethnic minorities may be more negatively impacted by healthcare costs. This study examined the relationship between insurance type and adolescents' cost-related unmet health needs overall and by race and ethnicity and whether parents are immigrants.

Enhancing Pediatric Bone Age Assessment Using Artificial Intelligence: Implications for Orthopedic Surgery.

Background Bone age assessment is a critical tool in pediatric orthopedic surgery, guiding treatment decisions for growth-related disorders and surgical interventions. Traditional methods, such as the Greulich-Pyle and Tanner-Whitehouse techniques, rely on manual interpretation of hand and wrist radiographs, making them time-intensive and susceptible to inter-operator variability. Artificial intelligence (AI) has emerged as a promising tool to enhance accuracy, efficiency, and standardization in skeletal maturity assessment.

The effect of a 10-week field-oriented transition programme for new graduate registered nurses in critical care.

Background: The turnover rate of new graduate registered nurses in critical care is high as they have trouble adapting to the field. Various transition programmes are being applied, but the effectiveness thereof remains controversial.

Aim: This study examined the effects of a 10-week field-oriented training programme for new graduate registered nurses in critical care setting using the Kirkpatrick model.

Atlantoaxial Instability in Neurofibromatosis Type 1: A Case Report.

Introduction: Neurofibromatosis (NF) is a cluster of conditions in which tumors grow in the nervous system. Even though the spine is the most common site of skeletal involvement in NF type 1 (NF-1), cervical spinal anomalies are infrequent.

Case Report: The atlantoaxial joint is a critical transitional zone in the cervical spine and is prone to instability.

Recent Advances in Cardiac Resynchronization Therapy: Current Treatment and Future Direction.

Cardiac Resynchronization Therapy (CRT) has been established as a major component of heart failure management, resulting in a significant reduction in patient morbidity and death for patients with increased QRS duration, low left ventricular ejection fraction (LVEF), and high risk of arrhythmias. The ability to synchronize both ventricles, lower heart failure hospitalizations, and optimize clinical outcomes are some of the attractive characteristics of biventricular pacing, or CRT. However, the high rate of CRT non-responders has led to the development of new modalities including leadless CRT pacemakers (CRT-P) and devices focused on conduction system pacing (CSP).

Molecular characterization of Pseudomyxoma peritonei with single-cell and bulk RNA sequencing.

Pseudomyxoma peritonei (PMP), a rare condition characterized by mucinous ascites in the peritoneal cavity, often leads to a poor prognosis. However, omics profiling of this disease remains significantly underexplored. Here, we present single-cell transcriptomic profiling of five PMP cases to identify cell type-specific gene features associated with PMP pathogenesis.

Home blood pressure monitoring and mobile health application practices among pregnant persons with and at risk of hypertensive disorders of pregnancy.

Objectives: To examine training in and current home blood pressure monitoring (HBPM) practices in pregnancies with hypertensive disorders of pregnancy (HDP) or risk factors for HDP; and to explore interest in using mHealth applications for communicating with healthcare providers.

Study Design: A cross-sectional survey was conducted on HBPM practices/training and interest in using mobile health (mHealth) applications among pregnant persons at an academic medical center.

Outcome Measures: The main outcomes measured were the proportion of participants who received training for HBPM, and the proportion interested in using mHealth applications for communication with providers related to managing HDP.

Dynamic Tracking of Tumor Microenvironment Modulation Using Kaede Photoconvertible Transgenic Mice Unveils New Biological Properties of Viral Immunotherapy.

This study utilized a novel photoconvertible mouse tumor model to track immune cell trafficking upon treatment with an investigational viral immunotherapy (CAN-2409), revealing enhanced T-cell responses after viral immunotherapy associated with local proliferation of T cells within tumors that could further enhance antitumor efficacy in combination with immune checkpoint inhibitors. These findings define temporally and spatially distinct interactions of immune cells that could be harnessed by novel therapeutics.

Family caregivers' perception of pressure ulcer prevention devices and equipment for patients with cerebrovascular and spinal disease.

Background: Family caregivers play a crucial role in preventing pressure ulcers in patients with cerebrovascular and spinal diseases. Despite the availability of advanced devices, including Internet of Things(IoT) based smart mattresses, the adoption and effectiveness of these technologies are influenced by caregivers' experiences and perceptions.

Objective: To investigate the experiences and perceptions of family caregivers regarding pressure ulcer prevention devices and equipment, with a focus on the factors influencing the intention to adopt IoT-based smart mattresses.

Exploring the impact of insurance switching on the cost-effectiveness of population genetic screening for familial hypercholesterolemia to US payers.

Background: Widespread familial hypercholesterolemia screening requires a large upfront economic investment, but the health benefits and cost savings of cardiovascular disease prevention directed by screening occur over many years.

Objective: We evaluated the cost-effectiveness of population genetic screening for familial hypercholesterolemia compared to cascade testing to US payers while accounting for patient insurance switching between commercial and Medicare insurance.

Methods: We developed a hybrid decision-tree Markov model to assess genetic screening in 20-year-old adults over a lifetime horizon in which cohort members transitioned between commercial payers representing three commercial plans and Medicare.

A rhamnose-rich O-antigen of MP20 is required for symbiosis with .

a β-proteobacterium, forms a nitrogen-fixing symbiosis with many species of the large legume genus as well as with common bean ( L.). are considered to have evolved nodulation independently from the well-studied α-proteobacteria symbionts of legumes.

Demographic and Geographic Trends in First-Episode Psychosis: A Cross-Sectional Study of Hospital Discharge Data in Adolescents and Young Adults.

This cross-sectional study aimed to assess the demographic and geographic variations in the visit rate for first-episode psychosis (FEP), identify trends and diagnostic patterns, and explore factors associated with FEP visits in Nebraska. Inpatient and emergency department data spanning 2017-2021 were collected by the Nebraska Hospital Association (NHA). The study focused on Nebraska residents aged 14-35 admitted for FEP, identified through specific ICD-10 codes.

Trajectories of Cognitive Function and Predictors Among Older Adults in Korea for 8 Years: A National Panel Data Analysis.

This study aims to examine the trajectory of older adults' cognitive function over time and identify its predictors. Based on the model of neuroplasticity and cognitive reserve, participants' general characteristics as well as their physical, mental, and social factors were included as predictors of cognitive function. A latent growth model analysis was used to examine the trajectory of cognitive function and its predictors.

Durvalumab with or without bevacizumab with transarterial chemoembolisation in hepatocellular carcinoma (EMERALD-1): a multiregional, randomised, double-blind, placebo-controlled, phase 3 study.

Background: Transarterial chemoembolisation (TACE) is standard of care for patients with unresectable hepatocellular carcinoma that is amenable to embolisation; however, median progression-free survival is still approximately 7 months. We aimed to assess whether adding durvalumab, with or without bevacizumab, might improve progression-free survival.

Methods: In this multiregional, randomised, double-blind, placebo-controlled, phase 3 study (EMERALD-1), adults aged 18 years or older with unresectable hepatocellular carcinoma amenable to embolisation, an Eastern Cooperative Oncology Group performance status of 0 or 1 at enrolment, and at least one measurable intrahepatic lesion per modified Response Evaluation Criteria in Solid Tumours (RECIST) were enrolled at 157 medical sites including research centres and general and specialist hospitals in 18 countries.

Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy.

Neurodegenerative tauopathies are characterized by the deposition of distinct fibrillar tau assemblies, whose rigid core structures correlate with defined neuropathological phenotypes. Essential tremor (ET) is a progressive neurological disorder that, in some cases, is associated with cognitive impairment and tau accumulation. In this study, we explored tau assembly conformation in ET patients with tau pathology using cytometry-based tau biosensor assays.