Molecular Characterization of Colistin- and Carbapenem-Resistant : Mutations and Clonal Diversity in Pediatric Intensive Care Isolates.

Colistin- and carbapenem-resistant (ColR CrKp) cause important health problems in pediatric intensive care units (PICUs) due to its ability to harbor multiple resistance genes and spread of high-risk clones. In this study, molecular epidemiological characteristics, transferable resistance genes, and alterations of ColR CrKp isolated from PICU were investigated. Isolates were identified by MALDI-TOF MS, and antimicrobial susceptibility tests were performed using disk diffusion method, gradient strip test, and broth microdilution method.

Molecular detection and phylogenetic analysis of microsporidia in water and soil in Mosul city.

Background: Microsporidia are opportunistic intracellular parasites that cause a variety of illnesses in humans. There is little information available regarding the frequency of this parasite in human cases of diarrhea and cancer.

Aim: This study's primary objectives are to identify microsporidia in soil and water samples, determine the relationships between microsporidia by using sequencing analysis in the targeted area, and look into the genetic diversity of microsporidia originating from domestic, farm, and wild animals.

Prediction of human error probability in helicopter to ship transfer operation under an evidential reasoning extended CREAM approach.

Although the helicopter to ship transfer operation is rarely applied in ports around the world, some of the hub ports have encouraged it. The operational process poses challenges to safety due to the nature of the work to be completed by the ship crew. This article performs a systematic human error prediction to ensure safe helicopter to ship transfer operations under different circumstances since the human factor is becoming a significant contributor to maritime accidents.

Association of Quality of Life and Visual Function in Glaucoma with Tests of Structure and Function.

Prcis: In addition to standard automated perimetry tests, contrast sensitivity testing and macular analyses may predict changes in the quality of life in patients at different stages of glaucoma.

Purpose: To examine the relationship between functional and structural tests of visual function and the 25-item National Eye Institute-Visual Function Questionnaire (NEI-VFQ-25) and the 36-item Short Form Health Survey (SF-36) in patients with different stages of glaucoma.

Materials And Methods: Standard automated perimetry tests, optical coherence tomography scans, and contrast sensitivity (CS) testing were prospectively performed in 160 patients with glaucoma.

Progressive multifocal leukoencephalopathy in sarcoidosis successfully treated with pembrolizumab.

Progressive multifocal leukoencephalopathy (PML) is a severe, demyelinating disease of the central nervous system caused by JC virus infection. The disease can be seen in sarcoidosis patients without additional risk factors. Here, we present an individual with PML secondary to sarcoidosis treated with 8 doses of pembrolizumab, a Programmed Cell-Death-1 (PD-1) Immune Checkpoint Inhibitor who showed significant improvement.

Further Clinical Delineation of Prolidase Deficiency Associated with c.1103T>G Variant.

Introduction: Prolidase deficiency is a rare multisystemic disease associated with collagen metabolism. Clinical manifestations and age of onset are highly variable. Prolidase deficiency is caused by homozygous variants in the gene.

Development of an amperometric biosensor that can determine the amount of glucose in the blood using the glucose oxidase enzyme: Preparation of polyaniline-polypyrrole-poly(sodium-4-styrenesulfonate) film.

In this study, a new amperometric biosensor was developed for glucose determination. For this purpose, polyaniline-polypyrrole-poly(sodium-4-styrenesulfonate) film was prepared by electropolymerization of aniline and pyrrole with poly(sodium-4-styrenesulfonate) on a platinum plate. The best working conditions of the polyaniline-polypyrrole-poly(sodium-4-styrenesulfonate) film were determined.

Assessment of autoantibodies associated with intravenous immunoglobulin replacement therapy in children with primary immunodeficiency.

While it is known that immunoglobulin replacement therapy (IgRT) used in the treatment of primary immunodeficiency disorders (PIDs) can lead to the passive transfer of autoantibodies, there is no data indicating that these antibodies can cause clinical symptoms in patients. This study aimed to investigate the presence of autoantibodies and their clinical correlation in patients diagnosed with PIDs receiving IgRT. Paediatric patients who were diagnosed with PIDs, and administered IgRT at our immunology clinic between 1 January 2012 and 31 December 2021, were included in the study.

Relationship between serum vitamin D levels and the prevalence of knee osteoarthritis: A retrospective study on 3424 subjects.

Background: The extent of the association between vitamin D deficiency and knee osteoarthritis remains inadequately understood.

Objective: This study aimed to elucidate the relationship between vitamin D levels and knee osteoarthritis through a cross-sectional analysis.

Methods: This retrospective study involved an analysis of knee radiographs and serum 25-hydroxyvitamin D3 (25-(OH) vitamin D3) levels in a cohort of 3424 individuals (2901 women and 523 men).

Intraoperative and Postoperative Effects of Dexmedetomidine and Tramadol Added as an Adjuvant to Bupivacaine in Transversus Abdominis Plane Block.

We aimed to evaluate the intraoperative hemodynamics, opioid consumption, muscle relaxant use, postoperative analgesic effects, and possible adverse effects (such as nausea and vomiting) of dexmedetomidine and tramadol added as adjuvants to bupivacaine in the transversus abdominis plane block (TAP block) to provide postoperative analgesia. This was a prospective, randomized, controlled trial on patients who underwent laparoscopic cholecystectomy. After obtaining ethical approval at the Van Yuzuncu Yil University and written informed consent, this investigation was registered with ClinicalTrials.

The emergence of Klebsiella pneumoniae sequence type 395 non-susceptible to carbapenems and colistin from Turkey.

Purpose: OXA-48 producing Klebsiella pneumoniae is an emerging threat and outbreaks due to specific sequence types have been commonly reported. Here, we report an outbreak due to multidrug-resistant ST395 K. pneumoniae ST395.

Assessment of nutritional status and clinical outcomes: A comprehensive retrospective analysis of critically ill patients.

Assessing nutritional status is vital for understanding and managing patients' clinical conditions. Controlling Nutritional Status (CONUT) score is one of the most frequently used scores that evaluate caloric status, protein reserve, and immunological response estimation. This study assesses the critically ill patients' nutritional status and its relationship with patient-related factors and mortality.

Pharmacokinetics of letrozole and effects of its increasing doses on gonadotropins in ewes during the breeding season.

Letrozole is a non-steroidal, third-generation aromatase inhibitor used in humans. Although letrozole is not approved for use in animals, it is used off-label in cases of synchronization and infertility. The aim of this study was to determine the pharmacokinetics of letrozole after a single intravenous administration at three different doses in ewes during the breeding season and its effect on gonadotropins (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) at the beginning of proestrus.

Evaluation of lumbar lordosis in symptomatic individuals and comparative analysis of six different techniques: a retrospective radiologic study.

Purpose: The aim of this study; evaluate lumbar lordosis (LL) in symptomatic individuals with six different techniques and to examine the techniques comparatively. Thus, to provide an overview of lumbal lordosis and techniques.

Methods: Cobb L1-L5, Cobb L1-S1, Posterior Tangent, tangential radiologic assessment of lumbar lordosis (TRALL), vertebral centroid measurement of lumbar lordosis (CLL) and Risser Ferguson measurement techniques were used to assess LL from radiographs of 175 symptomatic adults.

Colorimetric sensor based on biogenic nanomaterials for high sensitive detection of hydrogen peroxide and multi-metals.

Hydrogen peroxide (HO) and heavy metals, which are among the wastes of the industrial sector, become a threat to living things and the environment above certain concentrations. Therefore, the detection of both HO and heavy metals with simple, low-cost, and fast analytical methods has gained great importance. The use of nanoparticles in colorimetric sensor technology for the detection of these analytes provides great advantages.

Bloody Stool: Is It Really Scary in Kids? Four Benign Cases.

Cefdinir is a third-generation oral cephalosporin used frequently in the pediatric population. The most common side effects of cefdinir are diarrhea, nausea and dyspepsia. The side effect of turning the stool color to red and giving a bloody appearance, which is alarming for both families and physicians, is very rare.

ameliorates acetic acid induced ulcerative colitis in rats.

Increased pro-inflammatory cytokines and oxidative stress contribute to the pathophysiology of ulcerative colitis (UC). is a plant with antioxidant and anti-inflammatory properties. We investigated the effect of an ethanolic extract of on an experimental UC model created using acetic acid.

Evaluation of systemic immune-inflammation index efficacy in predicting complicated appendicitis in pediatric emergency department.

Background: Acute appendicitis (AA) is one of the most important causes of acute abdominal pain in children who are admitted to the pediatric emergency department. This study aims to determine the usefulness of the systemic immune-inflammation index (SII) in predicting complicated appendicitis (CA) in pediatric patients.

Methods: The patients who underwent surgery with the diagnosis of AA were evaluated retrospectively.