Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans.

IKKα is a multifunctional serine/threonine kinase that controls various biological processes, either dependent on or independent of its kinase activity. However, the importance of the kinase function of IKKα in human physiology remains unknown since no biallelic variants disrupting its kinase activity have been reported. In this study, we present a homozygous germline missense variant in the kinase domain of IKKα, which is present in three children from two Turkish families.

A Pregnant Woman Who Underwent Laparoscopic Adrenalectomy due to Cushing's Syndrome.

Cushing's syndrome (CS) may lead to severe maternal and fetal morbidities and even mortalities in pregnancy. However, pregnancy complicates the diagnosis and treatment of CS. This study describes a 26-year-old pregnant woman admitted with hypertension-induced headache.

Internal hernia: complex diagnostic and therapeutic problem.

Introduction: Internal hernias are neglected, life threatening and generally mismanaged surgical pathologies. They may be either acquired or congenital. The mortality and morbidity rates differ between the types and unfortunately reports investigating them are very rare, with limited number of patients, and mostly case reports.

The correlation of the D-dimer test and biphasic computed tomography with mesenteric computed tomography angiography in the diagnosis of acute mesenteric ischemia.

Background: Early diagnosis is the main factor to improve the outcome of acute mesenteric ischemia (AMI). The goal of this study was to assess the correlation of the D-dimer test and biphasic computed tomography (CT) with mesenteric CT angiography for the diagnosis of AMI.

Methods: Selected consecutive patients with a clinical suspicion of AMI were admitted to the study.

Recurrent liver hydatid disease: when does it become symptomatic and how does one diagnose it?

Background: Echinococcosis is a zoonotic disease that mainly occurs in sheep-grazing areas. Recurrence of the disease and its diagnosis are relatively new areas of investigation due to the limited number of cases. The aim of this study was to evaluate the diagnosis of the symptomatic recurrent liver hydatid disease and the efficacy of abdominal ultrasonography (US).

Ultrasound evaluation of peritoneal catheter tunnel in catheter related infections in CAPD.

In cases of peritonitis and exit site infections it is important to determine the extent of involvement of the subcutaneous catheter tract. The assessment of such involvement by physical examination alone appears to be inadequate and insensitive. We examined the usefulness of ultrasound (US) examination of the catheter tract in delineating catheter related infections, and their relationship to each other and to peritonitis.

[Xanthogranulomatous cholecystitis mimicking carcinoma of gallbladder].

Xanthogranulomatous cholecystitis is an uncommon variant of chronic cholecystitis. Xanthogranulomatous cholecystitis may best be regarded as a tumor-like condition and should be included in the differential diagnosis of gallbladder carcinoma. We present a case of xanthogranulomatous cholecystitis which mimicked carcinoma of gallbladder.

[Case report: Acute abdomen and pelvic mass due to torsion of a wandering spleen].

Torsioned wandering spleen should be considered in patients who have an intrapelvic mass with acute abdominal symptoms. Nowadays, color Doppler US and CT are easily achievable and are highly accurate for indicating the correct diagnosing in such patients. Using these two modalities together will increase the ability for correct diagnosis.

[Case report: Inflammatory pseudotumor of the liver with target-like appearance].

Inflammatory pseudotumor of the liver, which is rarely seen, can mimic abscesses, metastases, peripheral cholangiocarcinomas and hepatocellular carcinomas. While it has no specific clinical and laboratory findings, detection of a "target-like appearance" in triphasic CT and MRI examination may be differentiated from other liver pathologies. In this report, triphasic CT and MRI findings of an inflammatory pseudotumor of the liver were presented.

[Detectability of intraperitoneal free air by ultrasonography].

Purpose: We evaluated the role of ultrasonography in the detection of pneumoperitoneum.

Materials And Methods: Eleven patients who had been diagnosed as acute abdomen and pneumoperitoneum were evaluated by ultrasonography and direct radiographies. An additional ultrasonographic feature named "scissoring technique" was also evaluated.

Bilateral obturator dislocation of the hip.

A case of a traumatic bilateral obturator dislocation of the hip and right side acetabular fracture in a 23-year-old man is presented. The patient was managed conservatively. After follow-up time of 24 months, the result was excellent.