Multi-drug loaded eugenol-based nanoemulsions for enhanced anti-mycobacterial activity.

Tuberculosis is one of the oldest bacterial infections known to mankind caused by . The aim of this research is to optimize and formulate a multi-drug loaded eugenol based nanoemulsion system and to evaluate its ability as an antimycobacterial agent and its potential to be a low cost and effective drug delivery system. All the three eugenol based drug loaded nano-emulsion systems were optimized using response surface methodology (RSM)-central composite design (CCD) and were found stable at a ratio of 1 : 5 (oil : surfactant) when ultrasonicated for 8 minutes.

Multisystem Inflammatory Syndrome in Adults Associated With COVID-19: A Case Series on the Importance of Early Diagnosis and Corticosteroid Therapy in Prognosis.

Multisystem inflammatory syndrome in adults (MIS-A) is a rare condition that can occur after an adult has been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It can occur anywhere between two and 12 weeks after the beginning of acute coronavirus disease 2019 (COVID-19) infection and is characterized by extrapulmonary multiorgan failure. It is primarily seen in young and previously healthy individuals.

Wigner distribution function approach to analyze MIMO communication within a waveguide.

Multiple-input-multiple-output (MIMO) communication is a technology to create high capacity wireless links. The main aim of this paper is to provide a foundation to mathematically model wireless chip to chip communication within complex enclosures. This paper mainly concentrates on modelling wave propagation between transmit and receive antennas through a phase space approach which exploits the relationship between the field-field correlation function (CF) and the Wigner distribution function (WDF).

Current management of diabetes patients with COVID-19.

Introduction: Diabetes mellitus (DM) and the 2019 coronavirus (COVID-19) appear to interact in both directions. There is mounting proof that patients with DM have a worse COVID-19 prognosis than those without it. Pharmacotherapy is also known to affect in view of the possible interplay between drugs and the pathophysiology of the above conditions in a given patient.

Current management of diabetes patients with COVID-19.

Introduction: Diabetes mellitus (DM) and the 2019 coronavirus (COVID-19) appear to interact in both directions. There is mounting proof that patients with DM have a worse COVID-19 prognosis than those without it. Pharmacotherapy is also known to affect in view of the possible interplay between drugs and the pathophysiology of the above conditions in a given patient.

Medial Humeral Epicondyle Fracture Incarcerated Into the Elbow Joint in an Adolescent Patient With Ulnar Nerve Palsy.

Medial humeral epicondyle fractures are seen in about one-fourth of all elbow fractures in the pediatric population. Though it seems to be a common occurrence, there is still controversy existing on the treatment aspects to date. Among these fractures, about one-fourth are seen incarcerated into the elbow joint and this is managed surgically.

Radiographical Evaluation of Morphological Alterations of Mandibular Third Molars: A Cone Beam Computed Tomography (CBCT) Study.

Introduction  Morphological changes or variations in the lower third molar can be of concern during the endodontic, orthodontic, or prosthetic intervention. The goal of the present study was to evaluate the morphological alterations in the roots and root canal of a mandibular third molar in Bhopal, Central India, on cone beam computed tomography (CBCT) images. Methodology CBCT scans of 277 mandibular molars, of both genders, between the ages of 18 and 60 years were assessed for the presence of root numbers, the configuration of the canal based on Vertucci's categorization, and a C-shaped canal.

Prevalence of Geohelminthic Infection and Its Risk Factors Among School Children in Thiruvananthapuram, Kerala, India.

Introduction Geohelminthic infections are the most common infections worldwide and affect the poorest and most deprived communities. School-age children typically have the highest intensity of worm infection. Currently, information on the prevalence of geohelminthic infestations among schoolchildren is scarce in Kerala.

Association of exosomal miR-96-5p and miR-146a-5p with the disease severity in dengue virus infection.

Exosomes are small extracellular vesicles secreted by cells and have a major role in cell-to-cell signaling. As dengue infection progresses from a mild to a severe form of infection, the exosome's microRNA (miRNA) composition might change, which may contribute to pathogenesis. In this study, a comprehensive analysis of serum exosomal miRNAs was performed and their involvement in dengue virus-induced disease progression in an Indian cohort was assessed.

Imagining and reading actions: Towards similar motor representations.

While action language and motor imagery both engage the motor system, determining whether these two processes indeed share the same motor representations would contribute to better understanding their underlying mechanisms. We conducted two experiments probing the mutual influence of these two processes. In Exp.

Progress Against Cancer in Kuwait: Trends in Incidence, Survival and Mortality.

Introduction: To assess progress against cancer, trends in incidence, survival and mortality need to be interpreted simultaneously.

Methods: Data were obtained from the Kuwait Cancer Registry (KCR) for all Kuwaiti children (0-14 years) and adults (15-99 years) diagnosed with one of 18 common cancers during 2000-2013, with follow-up for vital status to 31 December 2015. World-standardised average annual incidence and mortality rates were calculated for 2000-2004, 2005-2009, 2010-2013.

MATHEMATICAL MODELLING APPROACH OF THE STUDY OF EBOLA VIRUS DISEASE TRANSMISSION DYNAMICS IN A DEVELOPING COUNTRY.

Background: Ebola Virus causes disease both in human and non-human primates especially in developing countries. In 2014 during its outbreak, it led to majority of deaths especially in some impoverished area of West Africa and its effect is still witnessed up till date.

Materials And Methods: We studied the spread of Ebola virus and obtained a system of equations comprising of eighteen equations which completely described the transmission of Ebola Virus in a population where control measures were incorporated and a major source of contacting the disease which is the traditional washing of dead bodies was also incorporated.

Risk factors associated with COVID-19 in systemic lupus erythematosus: Results from a longitudinal prospective cohort.

Introduction: Patients with SLE (systemic lupus erythematosus) have a higher risk of infection due to dysregulated immune system as well as long-term use of immunosuppressants (IS). This could influence the risk of COVID-19 and its outcome.

Methods: We conducted a longitudinal prospective study across 15 rheumatology centres during the first wave of the pandemic to understand the risk factors contributing to COVID-19 in SLE patients.

APESTNet with Mask R-CNN for Liver Tumor Segmentation and Classification.

Diagnosis and treatment of hepatocellular carcinoma or metastases rely heavily on accurate segmentation and classification of liver tumours. However, due to the liver tumor's hazy borders and wide range of possible shapes, sizes, and positions, accurate and automatic tumour segmentation and classification remains a difficult challenge. With the advancement of computing, new models in artificial intelligence have evolved.

Exposure of combination of environmental pollutant, lead (Pb) and β-amyloid peptides causes mitochondrial dysfunction and oxidative stress in human neuronal cells.

Exposure to the environmental pollutant lead (Pb) has been linked to Alzheimer's disease (AD), in which mitochondrial dysfunction is a pathological consequence of neuronal degeneration. The toxicity of Pb in combination with β-amyloid peptides (1-40) and (25-35) causes selective death in neuronal cells. However, the precise mechanism through which Pb induces Alzheimer's disease, particularly mitochondrial damage, is unknown.

Cerebrotendinous Xanthomatosis: Report of Two Siblings With the Same Mutation but Variable Presentation.

Cerebrotendinous xanthomatosis (CTX), also known as CTX, is an extremely rare bile acid metabolic disorder caused by mutations in the cytochrome P450 family 27 subfamily A member 1 (CYP27A1) gene. This genetic disease is inherited in an autosomal recessive manner, and it affects the enzyme sterol 27-hydroxylase, which is involved in the bile acid metabolic process. It is distinguished by diarrhoea in infancy, early juvenile cataract, tendon xanthomas in adolescence, and progressive neuropsychiatric dysfunction in adulthood.

Gene fusions, micro-exons and splice variants define stress signaling by AP2/ERF and WRKY transcription factors in the sesame pan-genome.

Evolutionary dynamics of AP2/ERF and WRKY genes, the major components of defense response were studied extensively in the sesame pan-genome. Massive variation was observed for gene copy numbers, genome location, domain structure, exon-intron structure and protein parameters. In the pan-genome, 63% of AP2/ERF members were devoid of introns whereas >99% of WRKY genes contained multiple introns.

Artabotrys odoratissimus Bark Extract Restores Ethanol Induced Redox Imbalance and Toxicity in Hepatocytes and In Vivo Model.

Alcohol-induced oxidative stress is a key player in the development of liver diseases, and herbal alternatives are important means of ameliorating the hepatotoxic effects. The study aimed to evaluate the hepatoprotective potentiality of Artabotrys odoratissimus, an important medicinal shrub from the family Annonaceae. The phenolic compounds from bark ethanol extract (BEE) were detected using RP-HPLC.

Advances and perspectives for antimicrobial peptide and combinatory therapies.

Antimicrobial peptides (AMPs) have shown cell membrane-directed mechanisms of action. This specificity can be effective against infectious agents that have acquired resistance to conventional drugs. The AMPs' membrane-specificity and their great potential to combat resistant microbes has brought hope to the medical/therapeutic scene.

The Effect of School Bullying on Pupils' Perceived Stress and Wellbeing During the Covid-19 Pandemic: A Longitudinal Study.

Purpose: Establishing how the Covid-19 pandemic and related lockdowns have affected adolescent mental health is a key societal priority. Though numerous studies have examined this topic, few have focused on the wellbeing of pupils who experience school bullying. This is particularly important as pupils who experience bullying represent a vulnerable group at increased risk of mental illness.

In silico analysis revealed the potential circRNA-miRNA-mRNA regulative network of non-small cell lung cancer (NSCLC).

Background: The primary source of death in the world is non-small cell lung cancer (NSCLC). However, NSCLCs pathophysiology is still not completely understood. The current work sought to study the differential expression of mRNAs involved in NSCLC and their interactions with miRNAs and circRNAs.

Unsupervised landmark detection and classification of lung infection using transporter neural networks.

Supervised deep learning techniques have been very popular in medical imaging for various tasks of classification, segmentation, and object detection. However, they require a large number of labelled data which is expensive and requires many hours of careful annotation by experts. In this paper, an unsupervised transporter neural network framework with an attention mechanism is proposed to automatically identify relevant landmarks with applications in lung ultrasound (LUS) imaging.

Exotic Dark Matter Search with the CDEX-10 Experiment at China's Jinping Underground Laboratory.

A search for exotic dark matter (DM) in the sub-GeV mass range has been conducted using 205 kg day data taken from a p-type point contact germanium detector of the CDEX-10 experiment at China's Jinping underground laboratory. New low-mass dark matter searching channels, neutral current fermionic DM absorption (χ+A→ν+A) and DM-nucleus 3→2 scattering (χ+χ+A→ϕ+A), have been analyzed with an energy threshold of 160 eVee. No significant signal was found; thus new limits on the DM-nucleon interaction cross section are set for both models at the sub-GeV DM mass region.

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer with Peritoneal Metastasis-Indian Experience.

Ashwin K.R.  Peritoneal metastasis secondary to gastric cancer is associated with poor prognosis.