and Study to Assess Toxic Mechanisms of Hybrid Molecules of Quinone-Benzocaine as Plastoquinone Analogues in Breast Cancer Cells.

We managed to obtain three different series of 2,3-dimethyl-1,4-benzoquinones, named nonhalogenated and halogenated (brominated and chlorinated) PQ analogues, the molecular hybridization strategy. Sixteen of eighteen hybrid molecules were selected by the National Cancer Institute (NCI) of Bethesda for their antiproliferative potential against the full NCI 60 cell line panel. The hybrid molecules (, , and ) showed good growth inhibition at 10 μM concentration, particularly against breast cancer cell lines.

Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure-activity relationship, activity profile, mode of action, and molecular docking.

In an attempt to develop effective and potentially active antibacterial and/or antifungal agents, we designed, synthesized, and characterized thiolated CoQ analogs (CoQ1-8) with an extensive antimicrobial study. The antimicrobial profile of these analogs was determined using four Gram-negative bacteria, three Gram-positive bacteria, and three fungi. Because of the fact that the thiolated CoQ analogs were quite effective on all tested Gram-positive bacterial strains, including (ATCC® 29213) and (ATCC® 29212), the first two thiolated CoQ analogs emerged as potentially the most desirable ones in this series.

Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking.

In the present study, we designed and synthesized thiolated analogs () along with an extensive antimicrobial study. After the evaluation of the antibacterial and antifungal activity against various bacterial and fungal strains, we presented an initial structure-activity relationship study on these analogs. In particular, four thiolated analogs exhibited superior biological potency against some Gram-positive bacterial strains, including (ATCC 29213) and (ATCC 29212).

Oxidative Stress and Periodontal Disease in Obesity.

Periodontal disease is a chronic inflammatory disease of the jaws and is more prevalent in obesity. Local and systemic oxidative stress may be an early link between periodontal disease and obesity. The primary aim of this study was to detect whether increased periodontal disease susceptibility in obese individuals is associated with local and systemic oxidative stress.

Electron paramagnetic resonance study of ZnAl(2)S(4) spinel.

Single crystals of ZnAl(2)S(4) spinel doped by paramagnetic Cr(3+) and Mn(2+) ions have been studied by the electron paramagnetic resonance (EPR) technique. The crystal field symmetry around the impurity ions has been determined from the angular behaviour of X-band EPR spectra. The anisotropic EPR signal of the Cr(3+) ions shows splitting into 31 narrow lines due to the super-hyperfine interaction between unpaired electron spins of the chromium centres and nuclear spins of six neighbouring Al(27) (I = 5/2) ions.