Vaccination of patients with encephalomyelitis disseminata.

The aetiopathogenesis of Encephalomyelitis disseminata (multiple sclerosis) is not yet fully understood. It is thought to involve an immunopathological process, with various exogenic factors considered to be possibly responsible for inducing the disease or causing acute exacerbations. In the literature the following factors are described as having the capacity to interfere directly or indirectly in immunoregulatory mechanisms: infectious diseases, gravidity, various types of trauma, non-infectious diseases, and drugs, but also physical strain and vaccinations.

[Current trends in the development of vaccines].

The increasing knowledge of the function of bacterial toxins, of adhesion phenomena, and the structure of epitopes boost the development of new or better vaccines. This is also influenced by the synthesis of peptides and the rapid progress in the field of genetic engineering. New vaccines against bacterial, viral, and parasitic infections may be expected.

Allergic encephalomyelitis in rats - toxicity assay for pertussis vaccines.

Levine produced encephalitis in Lewis rats after injection of pertussis vaccine together with spinal cord tissue of guinea-pigs. This animal model was used as an assay for the possible side-effects of pertussis vaccines prepared from whole bacteria or with extracted antigens. Wistar and Lewis rats were injected with a mixture of guinea-pig spinal cord and cFA together with vaccines into the pad of each hind food.