Publications by authors named "O ZAHRADNICEK"
Article Synopsis
- - Boron may improve the effectiveness of proton beam therapy in cancer treatment by enhancing cell damage in the targeted Bragg peak region through a specific nuclear reaction, although some studies have questioned this claim.
- - Experiments with prostate cancer and glioblastoma cells using 190 MeV proton beams showed that boron (from sodium mercaptododecaborate) significantly increased cell killing, especially at low concentrations and in the Bragg peak area.
- - The beneficial effects of boron occur through rare proton-boron reactions generating alpha particles, which lead to enhanced cell death, and this response seems to be amplified through interactions between cells, highlighting its potential for clinical use in treating certain tumors.
Hyperthermia along with hydrocortisone (HC) are proven teratogens that can negatively influence embryo development during early pregnancy. Proliferation of cells is one of the main developmental processes during the early embryogenesis. This study was focused on testing the effect of elevated temperature and HC addition on proliferation of cells in in vitro cultures.
View Article and Find Full Text PDFCancer and ionizing radiation exposure are associated with inflammation. To identify a set of radiation-specific signatures of inflammation-associated genes in the blood of partially exposed radiotherapy patients, differential expression of 249 inflammatory genes was analyzed in blood samples from cancer patients and healthy individuals. The gene expression analysis on a cohort of 63 cancer patients (endometrial, head and neck, and prostate cancer) before and during radiotherapy (24 h, 48 h, ~1 week, ~4-8 weeks, and 1 month after the last fraction) identified 31 genes and 15 up- and 16 down-regulated genes.
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- The study investigates the role of Eda protein in tooth development, specifically focusing on incisor germs in mice and how its absence affects tooth formation.
- Researchers employed 3D reconstruction, expression analysis, cell lineage tracing, and western blotting to analyze the impact of Eda's absence on early tooth development stages.
- Results showed that a lack of Eda led to changes in the expression of key developmental factors, resulting in smaller enamel knots and ultimately causing the formation of hypoplastic incisors.
Boron derivatives have great potential in cancer diagnostics and treatment. Borocaptates are used in boron neutron capture therapy and potentially in proton boron fusion therapy. This work examines modulation effects of two borocaptate compounds on radiation-induced DNA damage.
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