Publications by authors named "O Yumrutas"
Origanum syriacum Induces Apoptosis in Lung Cancer Cells by Altering the Ratio of Bax/Bcl2.
Anticancer Agents Med Chem
January 2025
Background: The lung cancer is the leading cause of death worldwide. Although methods such as surgery, chemotherapy, radiotherapy, and immunotherapy are used for treatment, these treatments are sometimes inadequate. In addition, the number of chemotherapeutic agents used is very limited, and it is very important to use new natural agents that can increase the effect of these methods used in treatment.
View Article and Find Full Text PDFSchiff bases (imines or azomethines) are versatile ligands synthesized from the condensation of amino compounds with active carbonyl groups and used for many pharmaceutical and medicinal applications. In our study, we aimed to determine the cytotoxic, antifungal and larvicidal activities of biologically potent bis-sulfonamide Schiff base derivatives that were re-synthesized by us. For this aim, 16 compounds were re-synthesized and tested for their cytotoxic, antifungal and larvicidal properties.
View Article and Find Full Text PDFThe aim of this study was to examine the in vivo wound healing potential of Hedge (endemic to Turkey) on excision and incision wound models in diabetic rats. Male Wistar albino rats, 3-4 months old and weighing 180-240g were used. The animals were randomly divided into five groups including Control, Vehicle and Fito reference, and two different concentrations (0.
View Article and Find Full Text PDFArticle Synopsis
- Advances in genomic technologies have identified numerous tumor markers but adapting these markers for clinical use is challenging due to RNA instability.
- In this study, researchers analyzed miRNA expression in salivary gland tumor samples, finding that levels of specific miRNAs (miR-200a and miR-373) were significantly upregulated while others (miR-30c) were downregulated compared to healthy tissues.
- These miRNA expression patterns correlated with important clinical features like perineural invasion and lymph node metastasis, indicating their potential role in diagnosing different types of salivary gland tumors.
Article Synopsis
- Transcribed ultra-conserved regions (T-UCRs) are long non-coding RNA molecules that are highly conserved across humans, rats, and mice, potentially playing a role in developmental processes.
- A study involving 42 patients with impacted mandibular third molars found that specific T-UCRs (uc.38, uc.112, and uc.338) had significantly increased expression in dental follicle tissues, indicating their clinical relevance.
- The findings suggest that these T-UCRs may be involved in the molecular changes associated with dental follicle tissues during the presence of impacted teeth, regardless of the patients' demographic traits.