Publications by authors named "O Yu Slominskyi"
Article Synopsis
- Fibrinogen is a complex plasma protein with αC-domains crucial for processes like blood clot formation, platelet aggregation, and cell interactions.
- Specific truncated forms of fibrinogen were created to study the roles of its N-terminal and C-terminal sub-domains.
- Results showed that both sub-domains contribute to fibrin polymerization and platelet aggregation, with the N-terminal being more influential in aggregation and the C-terminal significantly impacting cell viability and cancer cell migration.
[Activation of key proenzymes of the blood coagulation system by the fibrin E fragment].
Ukr Biokhim Zh (1999)
October 2002
Plasminogen and prothrombin are key proenzymes of fibrinolytic and clotting system. It is known that they can be activated by indirect activators streptokinase and staphylocoagulase. In this paper it is shown that fibrin E fragment purified from DD-E complex induced catalytic activity in plasminogen and clotting activity in prothrombin.
View Article and Find Full Text PDFIn review the results of investigation of plasminogen(Pg) activation by antiplasminogen monoclonal antibody IV-1c have been presented. Antigenic determinant of IV-1c was localized in Val709-Gly718 site of Pg protease domain. IV-1c completely inhibited the Pg activation by streptokinase, but increased the rate of Pg activation by t-PA and urokinase.
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