Publications by authors named "O Yu Shagaleeva"
High-grade serous ovarian carcinoma (HGSOC) remains the most common and deadly form of ovarian cancer. However, available cell lines usually fail to appropriately represent its complex molecular and histological features. To overcome this drawback, we established OVAR79, a new cell line derived from the ascitic fluid of a patient with a diagnosis of HGSOC, which adds a unique set of properties to the study of ovarian cancer.
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- Inflammatory bowel diseases involve ongoing inflammation in the intestines and changes in gut microbiota, which can be influenced by outer membrane vesicles (OMVs) that contain polysaccharide A (PSA).
- The study used a mouse model of intestinal colitis induced by sodium dextran sulfate (DSS) and examined the effects of OMV treatment by assessing disease severity and gut tissue health through disease activity index (DAI) and histology.
- Results indicated that OMV treatment improved intestinal healing and altered microbiota composition, highlighting OMVs’ potential as both anti-inflammatory agents and facilitators of microbiota recovery.
The anti-inflammatory properties of Bacteroides fragilis vesicles were studied in a rat model of dextran sodium sulfate-induced colitis. According to the histology results, addition of B. fragilis vesicles to the therapy promoted colon repair.
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- Inflammatory bowel diseases (IBD) are widespread but often show no symptoms early on, highlighting the need for effective, non-invasive diagnostic methods.
- This study proposes a technique to monitor IBD development by analyzing volatile organic compounds (VOCs) produced by gut microbiota using HS GC/MS during different inflammation stages in a rat model.
- Results showed significant changes in the metabolomic profile, particularly in short-chain fatty acids, during acute and remission phases of IBD, indicating potential biomarkers for early detection and monitoring of the disease.
Article Synopsis
- Microorganisms and their hosts communicate through secreted proteins and small molecules, including volatile compounds (VOCs) like butyrate and propionate, which impact intestinal and immune functions.
- The study focuses on analyzing the VOC secretome of specific bacteria from the intestinal microbiota, particularly their outer membrane vesicles (OMVs), which may have effects beyond the gut.
- More than 60 VOCs were identified in bacterial culture media, including fatty acids and amino acid derivatives, with the first characterization of Bacteroides species' OMVs and their associated volatile compounds.