Publications by authors named "O Yousefian"
Article Synopsis
- Hyaluronic acid (HA) is widely used in moisturizers, but traditional formulas only work on the skin's surface, limiting their rejuvenating effects.
- A study compared a lotion containing multi-weight HA and antioxidants with a single-weight HA and ceramide lotion, focused on improving facial dryness and fine lines in 70 women aged 25-65 over eight weeks.
- Results showed that the multi-weight HA lotion significantly improved skin dryness, roughness, and fine lines as early as two weeks, indicating its better penetration and effectiveness compared to the single-weight HA lotion.
Background: Late potential (LP) elimination has been proposed as a surrogate endpoint for scar-related ventricular tachycardia (VT) ablation procedures. The characteristics, distribution, and predictors of persistent late potentials (pLPs) after ablation have not been studied.
Objective: The purpose of this study was to characterize the spatial distribution and features of pLP after catheter ablation of VT substrate with high-resolution mapping.
Article Synopsis
- Focused ultrasound (FUS) combined with microbubbles shows potential for enhancing drug delivery across the blood-brain barrier (BBB) in Alzheimer's disease, but current methods are limited by their reliance on MRI facilities or invasive procedures.
- A pilot study evaluated a new portable system, neuronavigation-guided FUS (NgFUS), in six mild to moderate Alzheimer’s patients, using real-time mapping of microbubble activity to ensure safety and efficacy during treatment.
- Results indicated that BBB opening was achieved in 5 out of 6 subjects, with significant correlations between cavitation dose, BBB opening volume, and increased levels of Alzheimer’s biomarkers, demonstrating the system's capability for real-time monitoring and safety in outpatient settings.
Article Synopsis
- Focused ultrasound (FUS) combined with microbubbles shows potential for opening the blood-brain barrier (BBB) to improve drug delivery in Alzheimer's disease, but current methods are limited to MRI-equipped settings or invasive implants.
- A pilot study involving 6 mild to moderate AD patients tested a new portable, non-invasive NgFUS system that monitored real-time microbubble activity to confirm safety and effectiveness during a single treatment session.
- The results indicated that BBB opening was successfully achieved in 5 out of 6 patients, with significant correlations observed between microbubble activity and BBB opening volume, alongside increases in Alzheimer-related biomarkers in the blood, suggesting effective drug delivery methods can emerge from this technology.
In this work we infer the underlying distribution on pore radius in human cortical bone samples using ultrasonic attenuation data. We first discuss how to formulate polydisperse attenuation models using a probabilistic approach and the Waterman Truell model for scattering attenuation. We then compare the Independent Scattering Approximation and the higher-order Waterman Truell models' forward predictions for total attenuation in polydisperse samples.
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