Publications by authors named "O Yamauchi"
Severe skin ulcer caused by taking lenvatinib after proton beam therapy.
Clin J Gastroenterol
August 2023
Article Synopsis
- - A 69-year-old man developed a large skin ulcer at the site of proton beam therapy for liver cancer after starting treatment with lenvatinib.
- - The ulcer worsened even after stopping lenvatinib, but eventually healed after about 4 months with topical and antibiotic treatment.
- - This is the first reported case linking lenvatinib use with skin ulcer formation following proton beam therapy, suggesting potential skin damage from the combined treatments.
Article Synopsis
- - The study aimed to identify risk factors for esophageal candidiasis (EC) in patients without immune issues at a community hospital, reviewing data from 7,736 patients who underwent a specific type of endoscopy between 2012 and 2018.
- - Out of these patients, EC was identified in 184 cases (2.4%), with significant risk factors found to include diabetes, use of proton pump inhibitors (PPIs), atrophic gastritis, advanced gastric cancer, and prior gastrectomy.
- - The study highlighted that advanced gastric cancer and gastrectomy posed the highest risks for severe EC, and recommended monitoring of EC development in patients using PPIs alongside these risk factors.
Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms.
View Article and Find Full Text PDFPurpose: The purpose of this study was to clarify the factors that influence the incidence of colorectal neoplasia in patients with type 2 diabetes mellitus (DM).
Study Design And Setting: Among a total of 1176 patients who underwent total colonoscopy at our hospital, we retrospectively analyzed 168 patients with type 2 DM. Univariate and multivariate logistic regression analyses were then performed to identify the risk factors associated with colorectal neoplasia.
To gain insights into the role of the proximal indole ring in the redox-active metal center as seen in galactose oxidase, we prepared the Cu(II)-salen-type complexes having a pendent indol-3-ylmethyl (1), methyl (2) or benzyl (3) group substituted on the ethylenediamine moiety and investigated the structures and redox properties by various physicochemical methods and theoretical calculations. Neutral complexes 1, 2, and 3 showed no significant difference in the UV-Vis-NIR and EPR spectra. One-electron oxidation of 1, 2, and 3 by addition of 1 equiv.
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