Publications by authors named "O Will"
Article Synopsis
- Magnesium (Mg) alloys, particularly those with gadolinium, are emerging as promising materials for temporary bone implants due to their biocompatibility and mechanical properties, presenting a potential replacement for traditional titanium and stainless-steel implants.
- A study involving rat tibias over various time periods (10, 20, and 32 weeks) used advanced imaging techniques to evaluate the implants' degradation behavior and their integration with bone tissues.
- Results indicate that the Mg-xGd implants not only form a stable degradation layer and support bone remodeling similar to titanium but also do not accumulate harmful levels of Mg or Gd in organs, making them suitable for use in bone repair.
Article Synopsis
- The intestinal barrier acts as a crucial defense against harmful substances, and issues like "leaky gut" can lead to various diseases.
- Two novel Lactobacillus reuteri strains (PTA-126787 and PTA-126788) isolated from chickens show promise in maintaining intestinal integrity, demonstrating safety and efficacy in reducing alcohol-induced leaky gut in rats and mice.
- The strains are phylogenetically similar to human L. reuteri, and one strain displays a unique orange pigmentation linked to a potential mechanism for activating the AhR transcription factor involved in gut and immune regulation.
Introduction: The treatment landscape for advanced/metastatic renal cell carcinoma (aRCC) has evolved quickly with the introduction of immunotherapies as a first-line treatment option. This study examined the preferences of patients with aRCC to better understand the characteristics of preferred treatments and the tradeoffs patients are willing to make when choosing treatment.
Methods And Materials: An online, cross-sectional survey was conducted in the US from May to August 2022 with adult patients with aRCC.
The immune system plays an important role in fracture healing, by modulating the pro-inflammatory and anti-inflammatory responses occurring instantly upon injury. An imbalance in these responses can lead to adverse outcomes, such as non-union of fractures. Implants are used to support and stabilize complex fractures.
View Article and Find Full Text PDFA maternal vaccine and long-acting monoclonal antibody (mAb) were recently approved to protect infants against respiratory syncytial virus (RSV). We identified subgroups of pregnant people with different preferences for RSV preventives and respondent characteristics associated with subgroup membership. An online survey, including a discrete choice experiment (DCE), was conducted among US pregnant people.
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