Publications by authors named "O Welting"
Innervation of the intestinal mucosa by the sympathetic nervous system is well described but the effects of adrenergic receptor stimulation on the intestinal epithelium remain equivocal. We therefore investigated the effect of sympathetic neuronal activation on intestinal cells in mouse models and organoid cultures, to identify the molecular routes involved. Using publicly available single-cell RNA sequencing datasets we show that the α isoform is the most abundant adrenergic receptor in small intestinal epithelial cells.
View Article and Find Full Text PDFBackground: SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn's disease (CD), suggesting a role in inflammation.
Results: We report the development of the first small molecule SP140 inhibitor (GSK761) and utilize this to elucidate SP140 function in macrophages.
Article Synopsis
- Vagus nerve stimulation (SpNS) was tested in mice to see if it could reduce inflammation in inflammatory bowel disease (IBD) by targeting the splenic nerve and releasing norepinephrine (NE).
- Mice received stimulation during an induced colitis experiment, showing improved symptoms and lower inflammation markers compared to those with no stimulation.
- The results suggest SpNS may lower immune response activation, indicating potential for clinical application in IBD treatment for humans.
Article Synopsis
- Antimicrobial responses are crucial for gut health, and the study focuses on how miR-511 affects TLR4 responses, leading to increased intestinal inflammation.
- Mice lacking miR-511 showed less severe colitis symptoms and lower inflammatory cytokine levels compared to normal mice when exposed to DSS, indicating a protective role against intestinal inflammation.
- The research also identified Wdfy1 as a target of miR-511, suggesting that diminished WDFY1 levels in miR-511-deficient macrophages contribute to reduced immune responses from TLR3 and TLR4.
Background And Aims: Histone deacetylase inhibitors [HDACi] exert potent anti-inflammatory effects. Because of the ubiquitous expression of HDACs, clinical utility of HDACi is limited by off-target effects. Esterase-sensitive motif [ESM] technology aims to deliver ESM-conjugated compounds to human mononuclear myeloid cells, based on their expression of carboxylesterase 1 [CES1].
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