[Treatment of recurrent herpes labialis using a herpes simplex Type-I subunit vaccine. A prospective randomized double-blind multicenter study].

A herpes simplex type I subunit vaccine developed by Behring-Werke (Marburg/Lahn, FRG) was compared with placebo for therapeutic effectiveness in the treatment of recurrent orolabial herpes simplex in a multicentre study involving the major hospitals in Frankfurt/Main (n = 34), Hamburg (n = 18), Giessen (n = 17) und Kassel (n = 14). The effectiveness of the vaccine was judged on the reduction in the frequency of recurrences. Within the period of the 8-month study there was no statistically significant difference in the frequency of recurrences with vaccine or placebo.

[Experimental and clinical demonstration of the antiproliferative effect of a highly purified coal tar fraction in a special gel vehicle].

In this study a combination of clinical and experimental investigations demonstrates the antiproliferative effect of the coal tar-containing preparation Berniter. From a concentration of 70 micrograms/ml onwards (= 0.35 micrograms coal tar/ml) Berniter inhibits DNA synthesis of transformed human keratinocytes in vitro.

[Erythema exsudativum multiforme in rickettsiosis].

A patient with Mediterranean spotted fever with a typical exanthema acquired in South Africa developed erythema multiforme 12 days after the beginning of the rickettsial infection. The exanthema caused by the rickettsial infection as well as the erythema multiforme were effectively treated with tetracyclines.

[Kyrle's disease in diabetes mellitus and chronic terminal kidney failure].

The diagnosis of Kyrle's disease is based on both clinical and histological findings. The penetration of the keratin plug into the dermis is no pathognomonic feature but the result of pathologic events. Kyrle's disease may be caused and promoted by association with other diseases going along with hyperkeratosis and causing damage to tissue proteins by non-enzymatic glycosylation (e.