Models of care in secure services for people with intellectual and developmental disability: Implementing the Walkway to Wellness.

Background: Changes to policy around inpatient services for people with intellectual and developmental disability (IDD) who offend, have led to a need for services to reconsider their models of care. This has led to calls for more tailored, patient-centred care models, with less reliance solely on offence-related treatment programmes which can be unsuitable for a growing proportion of patients with more complex cognitive and behavioural difficulties. In response, the Walkway to Wellness (W2W) was developed at one National Health Service Trust providing secure services to people with IDD, with the intention of delivering a more collaborative, co-produced and goal-oriented care model that was better understood by staff and patient stakeholders.

A systematic review and narrative analysis of digital speech biomarkers in Motor Neuron Disease.

Motor Neuron Disease (MND) is a progressive and largely fatal neurodegeneritve disorder with a lifetime risk of approximately 1 in 300. At diagnosis, up to 25% of people with MND (pwMND) exhibit bulbar dysfunction. Currently, pwMND are assessed using clinical examination and diagnostic tools including the ALS Functional Rating Scale Revised (ALS-FRS(R)), a clinician-administered questionnaire with a single item on speech intelligibility.

Biocatalytic Enantioselective Synthesis of Atropisomers.

Atropisomeric compounds are found extensively as natural products, as ligands for asymmetric transition-metal catalysis, and increasingly as bioactive and pharmaceutically relevant targets. Their enantioselective synthesis is therefore an important ongoing research target. While a vast majority of known atropisomeric structures are (hetero)biaryls, which display hindered rotation around a C-C single bond, our group's long-standing interest in the control of molecular conformation has led to the identification and stereoselective preparation of a variety of other classes of "nonbiaryl" atropisomeric compounds displaying restricted rotation around C-C, C-N, C-O, and C-S single bonds.

Measuring the success of climate change adaptation and mitigation in terrestrial ecosystems.

Natural and seminatural ecosystems must be at the forefront of efforts to mitigate and adapt to climate change. In the urgency of current circumstances, ecosystem restoration represents a range of available, efficient, and effective solutions to cut net greenhouse gas emissions and adapt to climate change. Although mitigation success can be measured by monitoring changing fluxes of greenhouse gases, adaptation is more complicated to measure, and reductions in a wide range of risks for biodiversity and people must be evaluated.