Publications by authors named "O W Zhuk"
Article Synopsis
- * A study analyzed 34,128 COVID-19 patients across the US, South Korea, and Spain, revealing differences in gender and age demographics among countries.
- * Compared to influenza patients hospitalized from 2014-2019, COVID-19 patients tend to be younger, more often male, and have fewer comorbidities and lower medication use, indicating a need for tailored response strategies.
Article Synopsis
- The study investigated the safety of hydroxychloroquine, a drug used for rheumatoid arthritis, particularly considering its controversial use for COVID-19 pneumonia.
- It compared adverse events in patients starting hydroxychloroquine versus those starting sulfasalazine, analyzing data from multiple countries and focusing on severe events within a 30-day period.
- Results showed no significant increase in severe adverse events for short-term use of hydroxychloroquine compared to sulfasalazine, but long-term use may be linked to a higher risk of cardiovascular issues.
Background In this study we phenotyped individuals hospitalised with coronavirus disease 2019 (COVID-19) in depth, summarising entire medical histories, including medications, as captured in routinely collected data drawn from databases across three continents. We then compared individuals hospitalised with COVID-19 to those previously hospitalised with influenza. Methods We report demographics, previously recorded conditions and medication use of patients hospitalised with COVID-19 in the US (Columbia University Irving Medical Center [CUIMC], Premier Healthcare Database [PHD], UCHealth System Health Data Compass Database [UC HDC], and the Department of Veterans Affairs [VA OMOP]), in South Korea (Health Insurance Review & Assessment [HIRA]), and Spain (The Information System for Research in Primary Care [SIDIAP] and HM Hospitales [HM]).
View Article and Find Full Text PDFWe studied a set of Drosophila melanogaster strains that could be potentially suitable for testing a variety of mutagenic factors. Their genomes contained insertions of the enhancer trap P{lacW} in which the activity of the LacZ reporter is under the control of the reparation genes’ regulatory region. We demonstrated that the beta-galactosidase reporter, which is encoded by insertion of P{lacW} element in the gene mus209, is induced by irradiation in the cells of the salivary glands and wing imaginal discs.
View Article and Find Full Text PDFAims: Pituitary tumor-transforming gene (PTTG) is involved in multiple cellular pathways. We studied the development of liver fibrosis induced by thioacetamide (TAA) in knockout (PTTG-/-) and wildtype (PTTG+/+) mice.
Main Methods: Liver fibrosis in PTTG+/+ and PTTG-/- mice was induced by escalating dose TAA treatment (50-400mg/kg, i.