Publications by authors named "O W L Carter"
Background: There has been a resurgence of research into the potential therapeutic benefits of psychedelics for neuropsychiatric disorders. Classic psychedelics, such as psilocybin, exert complex effects on higher cognitive functions such as perception and awareness, but their impact on motor function remains unexplored. Moreover, there is a theoretical rationale for using psychedelics to promote motor retraining in certain neuropsychiatric conditions associated with motor dysfunction.
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- A study examined demographics and clinical experiences of patients with progressive pulmonary fibrosis (PPF) in five European countries, revealing limited knowledge on their journey and treatment options.
- Data from 1,335 patients indicated a mean onset age of 60.4 years, with a predominant demographic of white, non-smoking females.
- Notable findings included an average delay of nearly 8 months from first symptoms to physician visit and diagnosis, with common symptoms like dyspnoea and cough, and a high rate of prior misdiagnosis, particularly as chronic obstructive pulmonary disease (COPD).
Anticancer agents that exhibit catalytic mechanisms of action offer a unique multi-targeting strategy to overcome drug resistance. Nonetheless, many in-cell catalysts in development are hindered by deactivation by endogenous nucleophiles. We have synthesised a highly potent, stable Os-based 16-electron half-sandwich ('piano stool') catalyst by introducing a permanent covalent tether between the arene and chelated diamine ligand.
View Article and Find Full Text PDFThe novel hetero-dinuclear complex trans,trans,trans-[Pt(py)(N)(OH)(μ-OOCCHCHCONHCH-bpyMe)Ir(ppy)]Cl (Pt-Ir), exhibits charge transfer between the acceptor photochemotherapeutic Pt(IV) (Pt-OH) and donor photodynamic Ir(III) (Ir-NH) fragments. It is stable in the dark, but undergoes photodecomposition more rapidly than the Pt(IV) parent complex (Pt-OH) to generate Pt(II) species, an azidyl radical and O. The Ir(III)* excited state, formed after irradiation, can oxidise NADH to NAD⋅ radicals and NAD.
View Article and Find Full Text PDFEvidence suggests that MDMA-assisted psychotherapy (MDMA-AP) has therapeutic potential for treatment of psychiatric illness. We conducted the first comprehensive systematic review and meta-analysis of the side effects of MDMA-AP across indications. We also assessed the quality of side effects-reporting in published trials of MDMA-AP.
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