Publications by authors named "O W Howarth"

Article Synopsis
  • Sepsis negatively affects capillary function and oxygen delivery, potentially worsening patient outcomes.
  • Lower levels of immunoglobulin G2 do not contribute to severe flu complications, suggesting other factors may play a role in flu severity.
  • New research indicates that intravenous immunoglobulin may provide brain protection during sepsis by blocking harmful immune responses such as complement activation and apoptosis. *
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Bromine has been added to cis,trans,trans-1,5,9-cyclododecatriene under various reaction conditions. All expected direct addition products have been isolated, and their structures have been determined by microanalysis, NMR and X-ray crystallography. Advanced NMR techniques were used to determine solution conformations of several of the compounds, enabling comparison with the solid-state conformations obtained by crystallography.

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Aqueous peroxotungstates have been studied from pH 0.5 to 9.0, over a range of peroxide concentrations.

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Some arsenic compounds were the first antimicrobial agents specifically synthesized for the treatment of infectious diseases such as syphilis and trypanosomiasis. More recently, arsenic trioxide has been shown to be efficient in the treatment of acute promyelocytic leukemia. The exact mechanism of action has not been elucidated yet, but it seems to be related to arsenic binding to vicinal thiol groups of regulatory proteins.

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