Publications by authors named "O W Griffith"
Background: Neoantigen-targeting therapies including personalized vaccines have shown promise in the treatment of cancers, particularly when used in combination with checkpoint blockade therapy. At least 100 clinical trials involving these therapies have been initiated globally. Accurate identification and prioritization of neoantigens is crucial for designing these trials, predicting treatment response, and understanding mechanisms of resistance.
View Article and Find Full Text PDFBackground: Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II epitopes and performed a phase 1 clinical trial in triple-negative breast cancer patients with persistent disease on surgical pathology following neoadjuvant chemotherapy, a patient population at high risk of disease recurrence.
Methods: Expressed somatic mutations were identified by tumor/normal exome sequencing and tumor RNA sequencing.
Article Synopsis
- The first mammals that gave birth to live young had short pregnancies that involved some inflammation between the mother and the baby.
- Many marsupials, like kangaroos and wallabies, still keep this short pregnancy style, but their way of handling inflammation is different from other mammals called eutherians.
- In wallabies, they don't show a strong inflammatory reaction at the start of pregnancy, allowing them to have a longer gestation process compared to other marsupials.
Article Synopsis
- People diagnosed with cancer and their caregivers are overwhelmed by a massive amount of complex information due to advancements in cancer diagnostics and treatments.
- The commentary highlights both the opportunities to improve cancer care and the challenges posed by managing and understanding this large volume of data.
- It emphasizes the importance of integrating this information effectively into everyday cancer care to benefit patients and their support systems.