Publications by authors named "O Vittay"
Article Synopsis
- Somatic overgrowth disorders are rare conditions characterized by the abnormal enlargement of specific tissues, often related to the activation of the PI3K-AKT-mTOR signaling pathway, which is also implicated in cancer.
- Genetic variations can either enhance or inhibit this pathway, leading to excessive cell growth in particular areas, noted in disorders like CLOVES syndrome and Klippel-Trenaunay syndrome.
- Neurofibromatosis type 1 (NF1) involves faulty regulation of this pathway due to mutations in the NF1 gene, resulting in a range of growth abnormalities that can resemble other PIK3CA-related conditions, prompting a focus on their shared genetic and radiological features.
Background Impaired glucose metabolism is characteristic of several types of dementia, preceding cognitive symptoms and structural brain changes. Reduced glucose uptake in specific brain regions, detected using fluorine 18 (F) fluorodeoxyglucose (FDG) PET, is a valuable diagnostic marker in Alzheimer disease (AD). However, the use of F-FDG PET in clinical practice may be limited by equipment availability and high cost.
View Article and Find Full Text PDFWe aim to compare the outcomes in patients with atrial fibrillation detected after stroke (AFDAS) and their counterparts with known AF (KAF) presenting with large vessel occlusion (LVO) treated with mechanical thrombectomy (MT). This observational, prospective study included consecutive patients with acute LVO ischemic stroke of the anterior circulation with AFDAS, KAF and without AF. The primary study outcome was functional independence at 90 days after stroke.
View Article and Find Full Text PDFBackground: Although previous studies investigated the main predictors of outcomes after endovascular thrombectomy (EVT) in patients aged 80 years and older, less is known about the impact of the procedural features on outcomes in elderly patients. The aim of this study was to investigate the influence of EVT technical procedures on the main 3-month outcomes in a population of patients aged 80 years and older.
Methods: This observational, prospective, single-centre study included consecutive patients with acute LVO ischaemic stroke of the anterior circulation.
Background: Mechanical thrombectomy (MT) remains an effective treatment for patients with acute ischemic stroke receiving oral anticoagulation (OAC) and large vessel occlusion (LVO). However, to date, it remains unclear whether MT is safe in patients on treatment with OAC.
Aims: In our study, we performed a propensity-matched analysis to investigate the safety and efficacy of MT in patients with acute ischemic stroke receiving anticoagulants.