Publications by authors named "O Viklicky"
Background: Presensitized patients with circulating donor-specific antibodies (DSAs) before transplantation are at risk for antibody-mediated rejection (AMR). Peritransplant desensitization mitigates but does not eliminate the alloimmune response. We examined the possibility that subthreshold AMR activity undetected by histology could be operating in some early biopsies.
View Article and Find Full Text PDFThe aim of this prospective study was to assess the duration of culture-viable SARS-CoV-2 and to monitor the emergence of mutations in a cohort of 23 kidney transplant recipients (KTRs) from June 2022 to June 2023. Combined nares/oropharyngeal swabs were collected weekly starting as soon as possible after symptom onset. The time from symptom onset to a negative culture was 11 days (interquartile range, 8-14), while the time to negative reverse transcriptase quantitative polymerase chain reaction was 18 days (interquartile range, 15-30).
View Article and Find Full Text PDFBackground: Acute kidney injury in deceased donors (D-AKI) is one of the common causes of donor kidney discard. The risk factors for D-AKI and its impact on kidney transplantation outcomes are not yet fully understood.
Methods: This single-center, retrospective cohort study included 388 donors referred between June 2021 and December 2022.
Article Synopsis
- Despite progress in vaccinations, COVID-19 remains a significant risk for kidney transplant recipients (KTRs) due to their weakened immune response.
- A study of 120 KTRs revealed that their ability to produce neutralizing antibodies after receiving a booster shot of the mRNA vaccine BNT162b2 was noticeably lower and declined more rapidly than that of healthy individuals.
- Factors like age, reduced kidney function, and the use of mycophenolate mofetil were linked to this decreased antibody production, but overall, the type of antibodies produced was similar to those found in healthy subjects, without cross-reactivity to seasonal coronaviruses.
Background: We would like to present an unusual case of simultaneous stenosis of renal graft artery and vein diagnosed four months after transplantation. both treated by stent placement. Our aim is to point at the fact that renal graft venous stenosis is very rarely reported in the literature and - as it is not easy to diagnose by routine US - it could be overlooked.
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