Publications by authors named "O Veiseh"
Cell-based drug factories could produce therapies on demand inside patients.
View Article and Find Full Text PDFUncovering the interleukin-12 pharmacokinetic desensitization mechanism and its consequences with mathematical modeling.
CPT Pharmacometrics Syst Pharmacol
October 2024
Article Synopsis
- IL-12 is a promising immunotherapy that can stimulate a specific immune response (Th1), but its clinical usage is hampered by a phenomenon called desensitization, resulting in decreased effectiveness over time.
- Researchers explored the pharmacokinetic desensitization of IL-12 using mathematical modeling to validate mechanisms and create a predictive model.
- Two main causes of desensitization were identified: increased clearance and reduced bioavailability of IL-12, with a new model for reduced bioavailability fitting clinical trial data better than previous models, leading to potential strategies for improving IL-12 therapy.
Effective vascularization is crucial for repairing and enhancing the longevity of engineered tissues and organs. As the field advances, there is a vital need for efficient and reliable methods for assessing vascularization in real-time. The integration and performance of constructed biomaterials in living organisms rely on angiogenesis and vascularization, making it essential to evaluate vascular development and networks within biomaterials.
View Article and Find Full Text PDFPersistent tailoring of MSC activation through genetic priming.
Mol Ther Methods Clin Dev
September 2024
Mesenchymal stem/stromal cells (MSCs) are an attractive platform for cell therapy due to their safety profile and unique ability to secrete broad arrays of immunomodulatory and regenerative molecules. Yet, MSCs are well known to require preconditioning or priming to boost their therapeutic efficacy. Current priming methods offer limited control over MSC activation, yield transient effects, and often induce the expression of pro-inflammatory effectors that can potentiate immunogenicity.
View Article and Find Full Text PDFType 1 diabetes mellitus (T1DM) is a growing global health concern that affects approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune destruction of pancreatic β cells, leading to a disruption in glucose homeostasis.
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