Publications by authors named "O Vassal"
Article Synopsis
- The study investigates the pharmacokinetics (PK) of fluconazole in critically ill patients to identify optimal dosing regimens due to reported variability in drug response.
- A retrospective analysis included 36 critically ill and 16 non-critically ill patients, revealing that standard dosing often results in inadequate drug levels, particularly against certain pathogens.
- Findings suggest that higher loading doses are essential for meeting pharmacodynamic (PD) targets, particularly against stronger fungal infections, indicating a need for reconsideration of fluconazole use in severe cases.*
Background: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal metastases. However, HIPEC with cisplatin is associated with renal toxicity. Sodium thiosulfate (ST) has been shown to prevent cisplatin-induced toxicity.
View Article and Find Full Text PDFIntra-Abdominal Candidiasis (IAC) is frequent and associated with high mortality in intensive care unit (ICU) patients. Antifungal treatments may be overused due to a lack of diagnostic tools to rule out IAC. Serum 1,3-Beta-D-Glucan (BDG) concentrations are used to diagnose Candida infections, its concentration in peritoneal fluid (PF) may help to confirm or invalidate the diagnosis of IAC.
View Article and Find Full Text PDFWe report here a rare case of fatal rapidly progressive necrotizing gastrointestinal mucormycosis due to Mucor circinelloides f. circinelloides in the setting of community-acquired peritonitis, in an immunocompromised adult patient. Diagnosis was established by direct examination of peritoneal fluid showing hyphae consistent with mucormycosis confirmed by the culture.
View Article and Find Full Text PDFWhich injured patients with moderate fibrinogen deficit need fibrinogen supplementation?
Scand J Trauma Resusc Emerg Med
December 2021
Article Synopsis
- The study investigates the criteria for administering fibrinogen to patients with moderate fibrinogen deficit (MFD) following severe injuries, specifically looking at admission characteristics that correlate with fibrinogen use within 24 hours.
- Out of 1076 patients, 266 were found to have MFD-C (fibrinogen levels between 1.51-1.99 g/L), with nearly half of these patients receiving fibrinogen, particularly those with more severe injuries and compromised vital signs.
- The analysis identified that certain admission parameters, like shock index and hemoglobin levels, significantly influenced the likelihood of receiving fibrinogen, suggesting a clear relationship between these factors and the severity of the patient's condition.