[Changes in the content of bile acids and lipids in human bile during head-down tilt hypokinesia and their correction].

The spectrum of bile acids and bile lipids in men exposed to 120-day head-down tilt was investigated. The test subjects were subdivided in to four groups: group 1-bed rest per se, group 2-bed rest + exercise, group 3-bed rest + drugs normalizing calcium metabolism, and group 4-bed rest + exercise + drugs. It was anticipated that biliary concrements would primarily be formed in group 1 and 2 subjects.

[Lipid metabolic indices in man during head-down tilt hypokinesia and their correction].

Twenty one test subjects exposed to head-down tilt for 120 days were subdivided to four groups: Group 1--nine subjects used as controls, Group 2--three bed rested subjects who performed regular exercises, Group 3--four bed rested subjects who were given selected drugs, including Vitamin F-99 that influenced lipid metabolism, and Group 4--four bed rested subjects who performed regular exercises and received Vitamin F-99. At different stages of bed rest and recovery the content of lipoprotein fractions and lipids of different classes in serum was measured by thin-layer chromatography. The concentration of cholesterol in biliary lipids was determined.

[Lipid hydrolysis during antiorthostatic hypokinesia in man].

Using present-day techniques, we measured the activity of pancreatic lipase in the serum and duodenal juice, the activity of monoglyceride lipase in the duodenal juice, the concentration of lipoproteins in the bile, the activity of intestinal enzymes (monoglyceride lipase and alkaline phosphatase) and the concentration of lipid fractions in the feces. These parameters were determined in six test subjects who were exposed to head-down tilt (-4.5 degrees) for 120 days.

[Bile acid spectrum during 120 days of head-down tilt hypokinesia in man].

The composition of bile acids in the B and C portions of the duodenal juice of six essentially healthy test subjects exposed to 120-day head-down bed rest was investigated. As the exposure continued, the percentage content of bile acids conjugated with taurine increased and that of bile acids conjugated with glycine decreased. The rapid and significant decrease of the ratio of glycine conjugated to taurine conjugated bile acids suggests a specific modification of the synthetic function of hepatocytes under the above conditions.

[Lipid profile and lipolytic activity of the endogenous dense fraction of chyme and mucous deposits].

The lipid spectrum and lipolytic activity of the duodenal contents of an endogenous dense fraction of the chyme and mucous depositions were studied in small intestine. A considerable augmentation of the lipase activity was found in endogenous dense fraction of the chyme and in mucous depositions as compared to the duodenal juice activity.