Publications by authors named "O V Starkina"
Previous studies have shown that polyreactive antibodies play an important role in the frontline defense against the dissemination of pathogens in the pre-immune host. Interestingly, antigen-binding polyreactivity can not only be inherent, but also acquired post-translationally. The ability of individual monoclonal IgG and IgE antibodies to acquire polyreactivity following contact with various agents that destabilize protein structure (urea, low pH) or have a pro-oxidative potential (heme, ferrous ions) has been studied in detail.
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- Researchers studied how different substances can change how well a specific protein in our body, called secretory immunoglobulin A (sIgA), can grab onto germs like viruses and bacteria.
- They tested sIgA by exposing it to things like acidic solutions, free heme, and some metal ions to see how these affected its ability to bind to germs.
- They found that acidic solutions made sIgA bind better to various germs, more than the other treatments, which means it could help our body respond to infections more effectively.
It is time to celebrate the 125th anniversary of the first successful attempt to develop and use a specific high-titer antitoxic serum for treating diphtheria, a deadly infectious disease. This was followed by major advances in passive immunotherapy 75 years ago (production of pooled human IgG for subcutaneous injection) and 50 years ago (widespread technology for producing immunoglobulin preparations for intravenous administration). More than 200 tons of pooled human IgG are produced per year worldwide.
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