Publications by authors named "O V Shamova"
The C3f peptide is a by-product of regulation of the activated complement system with no firmly established function of its own. We have previously shown that C3f exhibits moderate antimicrobial activity against some Gram-positive bacteria . Presence of two histidine residues in the amino acid sequence of the peptide suggests enhancement of its antimicrobial activity at lower pH and in the presence of metal cations, particularly zinc cations.
View Article and Find Full Text PDFThe antimicrobial resistance crisis along with challenges of antimicrobial discovery revealed the vital necessity to develop new antibiotics. Many of the animal proline-rich antimicrobial peptides (PrAMPs) inhibit the process of bacterial translation. Genome projects allowed to identify immune-related genes encoding animal host defense peptides.
View Article and Find Full Text PDFGlioblastomas (GBMs) are the most malignant and intractable of all cancers, with an unfavorable clinical prognosis for affected patients. The objective was to analyze the sensitivity of GBM cells to the antimicrobial peptides (AMPs) cathelicidin (LL-37) and protegrin-1 (PG-1), both alone and in combination with chemotherapy, to predict overall survival (OS) in the patients. The study was conducted on 27 GBM patients treated in the neurosurgical department of the Almazov Medical Research Centre (Saint Petersburg, Russia) from 2021 to 2024.
View Article and Find Full Text PDFArticle Synopsis
- - Innate immunity in invertebrates provides effective antimicrobial peptides (AMPs) that combat drug-resistant infections, sparking interest in finding new β-hairpin AMPs from worm proteins with a BRICHOS domain.
- - Researchers discovered new BRICHOS AMPs from caecilians, a lesser-known group of vertebrates, revealing similarities to lung surfactants and suggesting a unique lung function.
- - The identified peptides show strong antibacterial properties against multidrug-resistant ESKAPE pathogens while being low in toxicity, indicating potential as a new antibiotic model and highlighting a previously unrecognized lung immunity mechanism.
Objective: Glioblastoma multiforme (GBM) is the most aggressive and fatal malignant primary brain tumor. The enhancement of the survival rate for glioma patients remains limited, even with the utilization of a combined treatment approach involving surgery, radiotherapy, and chemotherapy. This study was designed to assess the expression of IDH1, TP53, EGFR, Ki-67, GFAP, H3K27M, MGMT, VEGF, NOS, CD99, and ATRX in glioblastoma tissue from 11 patients.
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