Age-related features of Cytoflavin effectiveness during experimental myocardial ischemia.

Administration of Cytoflavin to young rats with experimental myocardial ischemia was followed by activation of mitochondrial enzymes and significant accumulation of ATP in the myocardium and blood plasma, but did not modulate the stability of cardiomyocyte membranes and signs of hypoxia. Cytoflavin increased the severity of metabolic disorders and depleted the energy reserves of cells in old rats with myocardial ischemia.

[Efficiency of mildronate in rats of different age with experimental-induced myocardial ischemia].

Under experimental myocardial ischemia in rats of 10 months treatment with mildronate resulted in essential changes in metabolism of cardiomyocites. This includes stimulation of aerobic and anaerobic ways of power supply of heart cells: activation of glycolysis, oxidative phosphorylation and oxidative pyruvate decarboxylation with restoration of adenosine triphosphate pool to intact rats level in myocardium, serum and erythrocytes with signs of stabilization of cardiomyocytes membranes and essential decrease of tissue hypoxia. Introduction of mildronate to old rats (24 months) with an experimental myocardium ischemia was accompanied by lesser expressed changes of metabolism: activation of glycolysis and oxidative pyruvate decarboxylation without stimulation of Crebs' cycle enzymes.

[Efficiency of trimetazidine treatment of experimental ischemic heart disease in age aspect].

Introduction of trimetazidine to 10-month-aged rats with experimental ischemic heart disease leads to an increase in carbohydrate utilization with energy purposes in myocardium, which is manifested by increasing activity of glycolysis enzymes with decreasing lactate level in myocardium, increasing activity of pyruvate dehydrogenase and citrate synthase in mitochondrial cardiomyocytes, and increasing ATP content in myocardium. This is accompanied by signs of stabilization of cardiomyocyte membranes and reduction in the degree of tissue hypoxia. The efficiency of trimetazidine decreases with increasing age: in 24-month-aged rats, the direction of changes is retained, but they are less pronounced.

[Erythrone system in aged patients with chronic cardiac insufficiency].

Basic mechanisms underlying the development of chronic cardiac insufficiency (CCI) in aged subjects were investigated in a randomized study of 30 patients with I-IV functional class CCI and preserved left ventricular systolic function. CCI affected the left side of the heart in 23 patients due to concurrent hypertensive disease and the right side in 7 patients with concomitant chronic broncho-pulmonary pathology. Mean age of the patients was 65 years.

[The prognosis for the occurrence of inflammatory genital diseases in girls and young women].

With the purpose of predicting probability of origination of inflammatory diseases of the genital organs among young female patients and their diagnosis during the early stages of development thereof, an algorithm has been worked out together with a mathematical model of probability of origination of genitalia inflammatory diseases at young age, based on prevailing social and economic and medical and biological risk factors. Correspondence between the secured indices across all samples among girls came up to 95.9%, that for the young women group was 99.