Publications by authors named "O V Romanova"
Background/objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies).
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- * A pilot screening program in Russia analyzed 202,908 newborns, finding 157 with trisomy 21, indicating a birth prevalence of 1:1,284, and explored their lymphocyte levels (TREC and KREC).
- * Results showed reduced TREC values in DS newborns, similar to extremely preterm infants, and significant KREC differences from the general newborn population, highlighting the need for deeper research into immune development in DS and better support from healthcare teams.
Article Synopsis
- The study aimed to investigate lung tissue changes in rats after administering baclofen, focusing on the expression of genes related to apoptosis (Bax and Bcl-2) in different lung cell types.
- Twenty Wistar rats were divided into four groups, with varying observation times after receiving baclofen, to assess the corresponding histological and gene expression effects.
- Results showed significant lung damage, including vascular issues and emphysema, peaking at 24 hours, with varying levels of Bax and Bcl-2 expression that indicated a dynamic response to baclofen administration.
Background: Postoperative delirium (POD) significantly affects patient outcomes after surgery, leading to increased morbidity, extended hospital stays, and potential long-term cognitive decline. This study assessed the predictive value of intraoperative electroencephalography (EEG) patterns for POD in adults.
Methods: This systematic review and meta-analysis followed the PRISMA and Cochrane Handbook guidelines.
Background: This study presents the findings of a newborn screening (NBS) pilot project for 5q-spinal muscular atrophy (5q-SMA) in multiple regions across Russia for during the year 2022. The aim was to assess the feasibility and reproducibility of NBS for SMA5q in diverse populations and estimate the real prevalence of 5q-SMA in Russia as well as the distribution of patients with different number of SMN2 copies.
Methods: The pilot project of NBS here was based on data, involving the analysis of 202,908 newborns.