Evaluation of sleep health documentation and sleep-related intervention by physiatrists treating musculoskeletal disorders: A retrospective investigation.

Background: Sleep health is linked to pain, function, and global health. Unfortunately, sleep health may not be consistently addressed as a part of musculoskeletal care.

Objective: To describe the frequency of sleep health documentation and intervention by musculoskeletal physiatrists.

Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor.

Background And Purpose: The potency of many 5-lipoxygenase (5-LOX) inhibitors depends on the cellular peroxide tone and the mechanism of 5-LOX enzyme activation. Therefore, new inhibitors that act regardless of the mode of enzyme activation need to be developed. Recently, we identified a novel class of thiazolinone-based compounds as potent 5-LOX inhibitors.

Acidic elements in histamine H(3) receptor antagonists.

Antagonists of the human histamine H(3) receptor (hH(3)R) often contain a second basic moiety, which is well known to boost affinity on this histamine receptor subtype. Here, we prepared compounds with acidic moieties of different pK(a) values to figure out that the hH(3)R tolerates these functionalities when added to a common pharmacophore blueprint. Depending on the acidic, electronic and steric features the designed ligands showed hH(3)R affinities in the nanomolar concentration range.

Plant derived omega-3-fatty acids protect mitochondrial function in the brain.

Perilla frutescens seed oil (PFSO) represents a rich source of unsaturated fatty acids, especially of omega-3 linolenic acid and is commonly used as herbal food supplement with beneficial effects on the vascular system. The present study investigated the effects of PFSO on the central nervous system (CNS) and provides new insight into potential mechanisms for protective properties of unsaturated fatty acids within the CNS. PFSO was administered chronically to guinea pigs and neuroprotective properties were assessed ex vivo in dissociated brain cells.