[Heat-shock protein HSP70 decreases activity of proteasomes in human neuroblastoma cells treated by amyloid-beta 1-42 with isomerized Asp7].

Experimental evidences indicate that heat-shock protein 70 (HSP70) can serve as a prospective therapeutic agent to treat Alzheimer's disease (AD). It has demonstrated a neuroprotective effect in vivo on mice models of AD. Moreover, HSP70 decreases oxidative stress in neurons induced by amyloid-β (Aβ42) and its more toxic form with isomerized Asp7 (isoAβ42).

Intracellular degradation and localization of NS1 of tick-borne encephalitis virus affect its protective properties.

Currently, many DNA vaccines against infectious diseases are in clinical trials; however, their efficacy needs to be improved. The potency of DNA immunogen can be optimized by targeting technologies. In the current study, to increase the efficacy of NS1 encoded by plasmid, proteasome targeting was applied.

[Rabies vaccines: Current status and prospects for development].

Rabies is an infectious disease among humans and animals that remains incurable, despite its longstanding research history. The only way to prevent the disease is prompt treatment, including vaccination as an obligatory component and administration of antirabies immunoglobulin as a supplement. Since the first antirabies vaccination performed in the 19th century, a large number of different rabies vaccines have been developed.

[Chromatin structure and transcription regulation in Saccharomyces cerevisiae].

Nucleosome organization of eukaryotic chromatin determines the DNA availability for regulatory factors during transcription. Nucleosome positioning at promoters is an important factor effecting gene expression. Recent studies showed that yeast promoters can be divided in two groups with the different chromatin organization.

[Transcriptional regulation of proteasomal genes in eukaryotes].

The ubuquitin-proteasome system is involved in degradation of many intracellular proteins and is necessary for proper functioning of the cell under normal conditions and its survival under stress conditions. In this review the general principles of structure and functioning of the ubiquitin-proteasome proteolytic system is considered. The main attention was paid for regulation of proteasomal genes expression, and specifically for discovery and analysis of Rpn4p transcription factor, an activator for proteasomal genes in Saccharomyces cerevisiae.