[Development and application of gas chromatographymass spectrometry method for quantitive determination of volatile N-nitrosamines in smoked meat products].

The article presents the results of experimental studies on the development of highly sensitive and selective chromatography-mass spectrometry technique for the determination of 9 N-nitrosamines in food samples (sausage products) using distillation and an automatic solid-phase extraction system on Coconut cartridges for sample preparation. In the elaborated conditions of sample preparation (distillation and solid-phase extraction) and chromatography-mass spectrometric analysis, we achieved a high recovery and efficiency of the separation of nine N-nitrosamines. The quantitation limit was at level of 0.

Diagnostics of Early Changes in the Immune System Due to Low Concentration of N-Nitrosamines in the Blood.

The concentration of N-nitrosamines (N-nitrosodimethylamine and N-nitrosodiethylamine) was measured in blood samples from children after consumption of drinking water with high content of nitrates (main group) or water meeting health standards (reference group). N-nitrosodimethylamine level in the blood from children of the main group differed from that in the reference group by 2.6 times (0.

[Clinical and epidemiological characteristics of hemorrhagic fever with renal syndrome in the North-West region of Russia].

The data of the literature and our own research of clinical and epidemiological features of hantavirus infection the North-West region of Russia, showing the loss of endemicity of hemorrhagic fever with renal syndrome. It is noted mostly airborne infection in young and middle-aged men, year-round nature of the disease with seasonal peaks. The clinical picture is moderately prevalent the disease with no or minimal systemic manifestation of hemorrhagic syndrome, often marked by thrombocytopenia, moderate dysfunction and kidney damage in half the time without reducing urine output.

[Evaluation of antimutagenic properties of powdered malt and polymalt extracts with the use of micronucleus test].

There were performed studies of the occurrence of cells with pathologies in the buccal epithelium of volunteers who consume drinks based on mixtures ofpowdered malt and polymalt extracts of buckwheat, peas, corn and barley. There was shown their impact on the stability of the genetic material of examined cases. There was established activation of apoptosis, which leads to the elimination of cells with cytogenetic deteriorations.

[THE DEVELOPMENT AND VALIDATION OF THE GAS CHROMATOGRAPHY METHOD AND VALIDATION DEVELOPMENT FOR THE ORGANIC CYANIDE (CYANOETHYLENE) DETERMINATION IN EXPIRED AIR].

There are presented results of experimental studies on the development of gas chromatography method for the cyan ethylene determination in expired air During the process of the study there was chosen and proved the capillary gas chromatography method; there were investigated and elaborated optimal parameters of the gas chromatography separation of cyanoethylene with associated hydrocarbons together with the sample preparation and quantitative measurement methods. There was achieved the optimal level of gas chromatography quantification method for the cyan ethylene determination at 0, 00012 mg/m3, with the method uncertainty not more than 25%. The method was tried during the medical and biological examination of groups of 6-8 years old children, living in the territory of exposition from the moment of the birth and in the control territory.