[Effect of sexual maturation on DD2R gene expression in fat body of Drosophila melanogaster females].

The expression of the DD2R gene was studied by in situ hybridization in the fat body (place of the synthesis of enzymes that degrade juvenile hormone) and ovarian follicular cells (place of the synthesis of 20-hydroxyecdysone) in young and sexually mature D. melanogaster females. It was demonstrated that the DD2R gene is expressed in the fat body, and its expression is higher in young females than in sexually mature females.

Role of D1- and D2-like receptors in age-specific regulation of juvenile hormone and 20-hydroxyecdysone levels by dopamine in Drosophila.

In Drosophila females, the precursor of 20-hydroxyecdysone (20E), ecdysone, is synthesized in the ovary follicular cells. Juvenile hormone (JH) is synthesized de novo in the specialized endocrine gland, corpus allatum (CA); JH degradation is carried out by the enzymes synthesized in the fat body (FB). Earlier we have shown that in Drosophila females, dopamine up- or down-regulates 20E and JH levels depending on the developmental stage.

[The DD2R gene expression level in the corpus allatum affects the fitness of female Drosophila melanogaster].

The effect of tissue-specific suppression of the dopamine D2-like receptor gene (DD2R) in the corpus allatum (CA), the gland that synthesizes juvenile hormone (JH) on the Drosophila melanogaster resistance to heat stress has been studied. A decreased expression of the DD2R gene in the CA has been found to substantially decrease the heat stress resistance of adult transgenic female, but not male, D. melanogaster compared to the control group, this phenomenon being weakly pronounced in juvenile flies.