Accumulation of Li Ions Triggers Changes in , , , and Transcription in the LiCl-Treated Human Umbilical Vein Endothelial Cells (HUVEC).

Changes in intracellular concentrations of Na and K are shown to alter gene expression. Another monovalent cation, Li, is well known as a medicine for treatment of psychiatric disorders, but mechanism of its action is obscure. Thus, it is important to evaluate the effect of Li on gene expression in endothelial cells.

[Karyological characteristics of Abies sibirica in the Middle Siberia].

Data on Abies sibirica karyotype structure have been obtained in five populations of Middle Siberia. Chromosome set (2n = 24) consists of 7 pairs of metacentric (I--VII), 4 pairs of submetacentric (VIII, X-XII) and a pair of intercentric (IX) chromosomes. Morphometric parameters of chromosome groups are similar in the populations studied.

[GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients].

Carriers of GSTTI gene deletion were found to be more subjected to a risk of emerging non-small-cell lung cancer (NSLC) than those of normal GSTT1(+) genotype. Study on the relation between GST gene polymorphism and cytogenetic indices in lung cancer patients has shown a significant excess of the group average level in cells with micronuclei in NSLC patients with GSTTI(-). The frequency of cells with micronuclei was higher in smoking patients with a mutant genotype than in smoking carriers of the GSTT1(+) genotype.

[Meiosis in the Siberian fir during microsporogenesis in conditions of arboretum].

Meiosis was studied in the Siberian fir (Abies sibirica Ledeb.) at the arboretum of the Sukachev Institute of Forest. Specific features of meiosis in planted trees have been described.

Hunting the mechanisms of self-renewal of immortal cell populations by means of real-time imaging of living cells.

The causes of the indefinite propagation of immortalized cell populations remain insufficiently understood, that hinders the research of such fundamental processes as ageing and cancer. In this study the interrelations between clonal proliferation and abnormalities of mitotic divisions in the immortalized cell line established from the mouse embryo were investigated with the aid of computerized microscopy of living cells. 3 mitoses with three daughter cells and 7 asymmetric mitoses which generated two daughter cells of conspicuously different sizes were registered among 71 mitotic divisions in the individual cell genealogy.