[Status of nucleoprotein synthesis in hematopoietic organs in mice with primary hypothyroidism].

A rate of incorporation of 3H-thymidine, 3H-uridine and 14C-glycine into the nucleoproteins of bone marrow, spleen, thymus and ileocecal lymph nodes was studied in BALB/c mice with hypothyrosis developed after administration of 1% KClO4 within a month. Distinct hypoplasia of bone marrow and spleen was found in the experimental animals; the synthesis of nucleoproteins was most impaired in bone marrow. The dependence of hemopoietic tissues on thyroid hormones was decreased as follows: bone marrow > spleen > thymus > lymph node.

[Comparative cytogenetic action of the antitumor antibiotics, carminomycin and rubomycin].

A comparative mutagenic effect of karminomycin and rubomycin in LD50 on the cells of the rat bone marrow (71 animals) was studied. It was found that karminomycin had a higher and more prolonged mutagenic effect than rubomycin. Both antibiotics induced mainly chromatin deletions and not so frequent reconstructions.