Publications by authors named "O V Korshunova"
Article Synopsis
- The effectiveness of photodynamic therapy (PDT) hinges on the interaction of photosensitizers, molecular oxygen, and visible light, leading to tumor cell damage and immune activation.
- PDT relies on the properties of photosensitizing drugs, particularly tetrapyrrole structures like porphyrins, but first-generation options faced challenges, such as skin sensitivity and poor tumor penetration.
- Second-generation photosensitizers are being developed to improve targeted therapy through advanced synthesis techniques, including bioconjugation and drug delivery systems to enhance tumor targeting and retention.
The study describes the influence of synthetic CaSiO/HAp powder biocomposite on the process of regeneration in osseous tissue in the alveolar ridges in terms of the morphological characteristics of the osteoplastic potential. The authors investigated the osteoinduction and osteoconduction "in vivo" processes during bone tissue regeneration in the mandible defect area of an experimental animal (rabbit). The possibility of angiogenesis in the graft as an adaptation factor was studied in the process of bone tissue regeneration.
View Article and Find Full Text PDFThe morphology and immunophenotype of female colostrum adherent cells with the help of CD3, CD31, CD34, CD45, CD68, vimentin, and osteocalcin antibodies panel was studied in short-term (6—7 days) culture in vitro. Approximately equal (1 : 1) ratio of fibroblast-like and rounded cells was observed in 20 % of cultural flasks. The cells with regular shape mixed with single fibroblasts were noted in 80 % of cultural flasks.
View Article and Find Full Text PDFQualitative and quantitative composition of enteric bifidoflora was studied in a group of 13 mother-infant pairs. Pure cultures of Bifidobacterium strains were isolated from feces and their species were identified by PCR with species-specific primers or by partial sequencing of 16S rDNA. The strains were compared by REP-PCR.
View Article and Find Full Text PDFIn this review recent information on relationships between the vaginal environment and microflora, including new taxonomic groups of microorganisms, is updated. The role of normal microflora in formation of vaginal colonization resistance and possible participation of some representatives of normal microflora, mainly nonsporulating anaerobic organisms, in the development of perinatal, neonatal and gynecological infectious complications are considered.
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