Statistical Shape Modeling of Biventricular Anatomy with Shared Boundaries.

Statistical shape modeling (SSM) is a valuable and powerful tool to generate a detailed representation of complex anatomy that enables quantitative analysis and the comparison of shapes and their variations. SSM applies mathematics, statistics, and computing to parse the shape into a quantitative representation (such as correspondence points or landmarks) that will help answer various questions about the anatomical variations across the population. Complex anatomical structures have many diverse parts with varying interactions or intricate architecture.

Statistical shape modeling of multi-organ anatomies with shared boundaries.

Statistical shape modeling (SSM) is a valuable and powerful tool to generate a detailed representation of complex anatomy that enables quantitative analysis of shapes and their variations. SSM applies mathematics, statistics, and computing to parse the shape into some quantitative representation (such as correspondence points or landmarks) which can be used to study the covariance patterns of the shapes and answer various questions about the anatomical variations across the population. Complex anatomical structures have many diverse parts with varying interactions or intricate architecture.

[Basal-luminal epithelial cell differentiation in prostate cancer is associated with epithelial-mesenchymal transition and epithelium migration in the mesenchyme].

Aim: In patients with prostate cancer to trace the pathway of the malignant cells of the basal layer of the prostate epithelium during their differentiation into luminal cells and/or migration in the mesenchyme.

Materials And Methods: We used histological and immunohistochemical staining of the markers of the basal layer of the prostate: cytokeratin 5 (CK5), E-cadherin and AMACR, and Western blot to assess the production of the same markers in epithelial and stromal compartments of malignant and normal prostate tissue in patients with prostate cancer.

Results: Our findings revealed that prostate cancer is associated with losing of the basal epithelial layer in the prostate tumor tissue, which is accompanied by a complete loss of CK5 secretion, increased levels of E-cadherin and AMACR in luminal epithelium and the emergence of cells producing E-cadherin and AMACR in the stromal compartment of the prostate.

[STATE OF HEPATIC HEMODYNAMICS IN TRANSPLANTATION OF ITS RIGHT PART WITH MEDIAN HEPATIC VEIN].

Peculiarities of regional hemodynamics in transplantation of right hepatic part with median hepatic vein were studied. The blood flow parameters — the volume portal blood flow (VPBF), linear speed of blood flow (LSBF), the resistance index (RI) in hepatic artery; phasic structure of the blood flow along hepatic veins were determined in 31 patients in accordance to ultrasonographic flowmetry data. Maximal value of VPBF was observed on a second postoperative day, minimal one —on the fourth day.

MARKERS OF THE PROSTATE BASAL LAYER CELLS ARE EFFECTIVE INDICATORS OF ITS MALIGNANT TRANSFORMATION.

Development of local or general forms of prostate cancer (PC) depends on formation of metastasis the biological nature of which is based on epithelial mesenchymal transition (EMT). ÅÌÒ presents highly conservative reversible program that is maintained by specific transcription factors which suppress E-cadherin expression and support production of mesenchymal polarity factors. The goal of this work was to study the functionally distinct markers in malignant prostate tissue of patients with prostate cancer using the histological evaluation, reverse polymerase chain reaction and immunobloting.