[Cytokine profile of chronic rhinosinusitis without polyps].

Introduction: Chronic rhinosinusitis (CRS) is the most common immunological ENT disease, which has several phenotypes. The heterogeneity of CRS is due to the peculiarities of their pathogenetic mechanisms - the system of cytokines plays the crucial significance. They are biologically active substances and present regulatory peptides that demonstrate an immunomodulatory and regulatory effects not only in the local level but the system level as well.

Dependence of blood biochemical parameters on various genotypes of the UGT1A1 gene associated with gilbert's syndrome.

Diagnosis of Gilbert's syndrome is based on the detection of homozygous carriage of an additional TA-repeat in the promoter of the UGT1A1 gene, leading to a decrease in the activity of the UGT enzyme. No large studies have been done in the Russian Federation on the prevalence of carriage of Gilbert's syndrome, as well as the biochemical and molecular profile of such patients. The aim of the study is to evaluate biochemical and molecular genetic parameters in patients with Gilbert's syndrome in Russia.

[The influence of the vitamin D3 level in the blood serum of lactase gene polymorphism on the development of chronic polypous rhinosinusitis].

The objective of the present study was to elucidate the possible correlations between the vitamin D level in the blood serum and lactase gene polymorphism (LCT-13910 T>C) in the patients presenting with chronic polypous rhinosinusitis (CPRS). The study included 50 patients with this condition and 14 subjects comprising the control group. The variants of lactase gene polymorphism (LCT-13910 T>C) were identified with the use of polymerase chain reaction (PCR) in real time.

Concept of Educational Assistance to Health Protection of the Individual.

The article describes the theoretical and practical need for the development of the concept of assistance to health protection of the individual in order to address the problem of health protection of students and teachers in the conditions of a higher pedagogical education. The problem of studying human health, its entirety, systemacity and connection with the environment attracts particular attention in recent years. This was one of the reasons to study the problem of "healthy lifestyle" as the qualitative characteristic of a human life aimed at health, due to the fact that a healthy lifestyle is one of the determinants of health.

[Topical problems and concepts of development of military otorhinolaryngology].

One of the primary objectives of military otorhinolaryngology is to provide specialized otorhinolaryngological aid to the sick,wounded, and injured servicemen during local armed conflicts and in times of peace. The military forces of the Russian Federation must have up-to-date, mobile, readily available, and many-level otorhinolaryngological service. The concept of further development of this service has been elaborated to ensure its balanced and sustainable functioning.