[Clinical and functional disturbances in epilepsy patients with schizencephaly].

Objective: To study the features of diagnosing and predicting structural epilepsy in children with schizencephaly (SE) based on the analysis of clinical, electrophysiological and neuroimaging results.

Material And Methods: Fifteen patients with epilepsy and SE (seven boys and eight girls), aged from 3 months to 14 years, were examined.

Results: Unilateral SE was detected in ten patients (closed - in four, open - in six), bilateral open SE was detected in five patients.

[Diagnostic and prognostic significance of the level of IgM antibodies to myelin basic protein in children with traumatic brain injury].

Objective: To study the content of antibodies to the basic protein of myelin IgM in the blood of children with traumatic brain injury for a comprehensive assessment of the severity and prediction of outcomes of TBI.

Material And Methods: 81 children with traumatic brain injury (TBI) of varying severity and 29 children of the comparison group aged 2 months to 18 years were examined, in whom the content of IgM antibodies in blood plasma was determined.

Results: In groups of children with different severity of TBI, the average content of IgM antibodies in the blood is higher than in children of the comparison group, and the values of IgM antibodies correlate with the severity of TBI.

[Phenotypic and neuroimaging differentiation of polymicrogiry in children].

Aim: To study the results of the examination of children and to assess the degree of correlation of cortical disorders with phenotypic and neuroimaging characteristics of polymicrogyria (PMG).

Material And Methods: An analysis of disease history, neurological data, semiotics of epileptic seizures, neuroimaging and electrophysiological results was performed in 27 patients with PMG.

Results And Conclusion: Correlations between the prevalence of cortical malformation and the increased frequency of abnormalities in internal organs, stigma of dysembryogenesis, cognitive and motor disorders are shown.

[New opportunities in the optimization of epilepsy treatment in adolescents].

In the pubertal period, the most severe forms of childhood epilepsy persist and are modified; genetically determined syndromes, atypical for early and late age periods, make their debut. Hereditary predisposition, instability of homeostatic mechanisms, neuroendocrine restructuring at the age of puberty and the influence of factors contributing to the realization of a genetic defect lead to a long-term transformation of mediator systems and formation of epileptic activity in adolescents. The authors present common approaches in the treatment and characterization of the modern antiepileptic drug perampanel, which is highly effective in treatment of patients with resistant forms of epilepsy.

[Diagnosis and correction of cognitive impairment in preschool age children with epilepsy].

Objective: To study cognitive impairment and the efficacy of hopantenic acid (pantogam) in children, aged from 4 to 7 years, with epilepsy and cognitive impairment.

Material And Methods: The study included 40 children with epilepsy treated with pantogam (the main group) and 23 children with epilepsy who did not receive pantogam (the comparison group). All children were diagnosed with cryptogenic epilepsy and symptomatic epilepsy.