Publications by authors named "O V Gutnikova"

Antihypertensive drug eprosartan from the group of angiotensin II receptor blockers was studied from the position of its effect on professionally significant psychophysiological qualities of train drivers, which were assessed with the help of psychophysiological tests. One hundred drivers with arterial hypertension were included into the study and 2 adequate groups were distinguished: 1st which consisted of 50 persons receiving eprosartan (600 mg/day), and 2nd which comprised 50 persons receiving placebo. Results of the study have showed that eprosartan did not lower professionally significant psychophysiological qualities of drivers.

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Examination of 72 individuals (including 62 workers of asbestos production and 10 silicosis patients) revealed that asbestos dust primarily causes hypoxemia followed by pulmonary ventilation disorders and characteristic X-ray signs of asbestosis. Hypoxemia is associated by reliable changes in functioning of left ventricle and central hemodynamics. Degree of hypoxemia appeared to correlate with echocardiographic signs of malfunction of left ventricle and chronic heart failure.

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Hygienic, clinical and epidemiologic screening was performed in staff of asbestos and cement goods production enterprise. Various dystrophic processes of pharynx and nasal cavity appeared to prevail among upper respiratory tract diseases. Average exposure to dust during 22 years at the stated production can lead to asbestosis 0-I stage, average exposure during 20.

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Hygienic, clinical, epidemiologic studies in primary woodworking and chipboard production workers showed that exposure to occupational hazards (wooden dust, formaldehyde and other chemicals of wooden origin) results in frequent allergy and irritation of upper respiratory tract and skin. High oncologic risk among woodworking production employees assigns the industry to a group with oncologic jeopardy. MAC for wooden dust should be corrected taking into account the chemicals (phenol, formaldehyde, furans et al.

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