[Effect of trans-ACPD, a specific agonist of glutamate interacting with metabotropic receptors, on synaptic transmission in the rat hippocampus].

Trans-ACPD, a cyclic analogue of glutamate, has been studied for its influence on field potentials and excitatory postsynaptic currents (EPSCs) in the CA1 layer. Being applied in concentration 50 microM and above, trans-ACPD completely and reversibly inhibited excitatory postsynaptic field potentials but has no effect on EPSCs. Trans-ACPD in the same concentration reversibly reduced the amplitude of antidromic population spike in the CA1 layer, but has an insignificant effect on antidromic population spike in the CA3 layer.

[Analysis of synaptic transmission in rat hippocampal slices using a modified method of potential fixation].

A new approach for the whole-cell recording in slices is suggested as simpler and less expensive one than those known before. Electrophysiological characteristics of excitatory postsynaptic currents are obtained. Two types of glutamate receptors are shown to be involved.

[Taurine-activated currents in isolated neurons of the rat cerebellum].

Taurine-activated currents in isolated neurons of the rat cerebellum were studied by voltage and "concentration" clamp methods. They were transmitted by potassium and chloride ions. The dose-response curve with the dissociation constant 2 x 10(-3) mol/l was obtained.