Publications by authors named "O V Bragina"
Most studies on CTCs have focused on isolating cells that express EpCAM. In this study, we emphasize the presence of EpCAM-negative and EpCAM CTCs, in addition to EpCAM CTCs, in early BC. We evaluated stem cell markers (CD44/CD24 and CD133) and EMT markers (N-cadherin) in each subpopulation.
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- Sepsis is a severe condition marked by inflammation and blood vessel dysfunction, leading to high hospital mortality rates, and new methods are needed to combat it.
- Research has shown that using drag-reducing polymers (DRPs) can enhance blood flow and oxygen delivery in the body, providing protection to brain cells in traumatic situations.
- In experiments with mice, DRPs improved microcirculation and oxygen supply, reducing harmful effects of sepsis compared to a control group that only received saline, indicating their potential as a treatment strategy for sepsis-related complications.
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- The study aimed to explore how eye tracking (ET) metrics relate to brain tissue oxygen levels in patients with moderate COVID-19 pneumonia.
- Conducted on 92 patients around 34 years old, it measured eye movement reactivity using mobile technology while assessing cerebral oxygenation through specialized equipment.
- Results showed a correlation between eye movement responses and oxygen saturation in the brain, indicating that oxygen levels significantly impact eye coordination during COVID-19 pneumonia.*
An early event in the pathology of traumatic brain injury (TBI) is a reduction in cerebral blood flow (CBF), which exacerbates secondary injury development and inhibits brain recovery. The endogenous cannabinoid system signalling (eCBs) might be critical in TBI recovery due to modulating synaptic activity and exerting neuroprotective and anti-inflammatory effects. In the brain, eCBs predominantly occur at cannabinoid receptor type 1 via the eCB 2-arachidonoylglycerol (2-AG).
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- The study aimed to evaluate the occurrence of posttraumatic cerebral ischaemia (PTCI) and monitor intracranial pressure (ICP) during the transportation of patients with severe traumatic brain injuries (TBI).
- It included 153 TBI patients, with findings showing that all displayed signs of PTCI, and that roughly 38% had ischaemia affecting both brain hemispheres.
- The results indicated that ICP significantly increased during transportation, particularly during vertical movement, with an average rise from 19.9 mm Hg to 26.1 mm Hg.