Features of Metabolism and Its Regulation in the Dynamics of Experimental Models of Metabolic Disorders.

Changes in the lipid and carbohydrate metabolism, adipokines, and growth factors during the development of metabolic disorders were studied in three mouse models: C57BL/6 (alimentary obesity), db/db (leptin-resistant obesity), and NOD (diabetes mellitus) lines. In the group of alimentary obesity, moderate fatty infiltration of the liver and hypertrophy of the adipose tissue, hyperglycemia, and increased concentrations of adiponectin, transforming growth factor β1 (TGF-β1), leptin, and cholesterol were detected. In the group of leptin-resistant obesity, multiple pathological changes in tissues, severe hyperglycemia and hyperleptinemia, hyperinsulinemia, and reduced concentrations of triglycerides, adiponectin, myostatin, and TGF-β1 were detected.

Effect of coal quality and preparation on the stamping performance and quality of coke.

This article presents the results of the research on real coal charges of different compositions intended for coking with loading into the chamber by the stamping method. The results of the study established that with an increase in the content of coal at a low stage of metamorphism and a decrease in the content of coal at a high stage of metamorphism in the charges, a decrease in the quality indicators of the coke obtained from them leads to a decrease in the yield of coke. At the same time, there is a gradual decrease in the compaction of the charges from 22.

Composition and polymerisation products influence on the viscosity of coal tar wash oil.

Wash oil is a fraction obtained by the distillation of coal tar and is primarily used for the absorption of light oil from coke oven gas. During operation, the oil undergoes polymerization and loses some components, necessitating the removal of the used oil and its replacement with fresh wash oil. The rheological properties of the studied oils were determined using a Brookfield DV2T rotational controlled-shear rate rheometer.

The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants.

Obesity develops largely due to genetic factors, with the genetic polymorphism of lipid metabolism enzymes being of particular importance. However, it is still unclear how the genetic variants of one of the key enzymes in lipid transport, lipoprotein lipase (LPL), are associated with the endocrine function of mesenchymal tissues in obesity. The current study was aimed at the investigation of the rs328 gene variant association with adipokines and myokines levels, as well as lipid metabolism indices in the blood of children and adolescents of both genders with obesity.

Study of Brewer's Spent Grain Environmentally Friendly Processing Ways.

Background: This article is devoted to the study of the effect of electrochemically activated water (catholyte with pH 9.3) on organic compounds of the plant matrix of brewer's spent grain in order to extract various compounds from it.

Methods: Brewer's spent grain was obtained from barley malt at a pilot plant by mashing the malt followed by filtration and washing of the grain in water and storing it at (0 ± 2) °C in craft bags.