[Therapeutic effect of acetylcysteine on rats with gentamicin-induced nephropathy].

Gentamicin (60 mg/kg, i.p., once per day for 10 days) produces a nephrotoxic effect in rats, which is manifesting by the epithelium necrosis of proximal convoluted tubules (especially of cortical nephrons), decreasing creatinine clearance, and increasing protein in the urine.

Structural-metabolic changes in histaminergic neurons of the rat hypothalamus in conditions of loss of bile.

The aim of the present work was to evaluate structural and metabolic changes in histaminergic neurons in hypothalamic nucleus E2 in rats in conditions of complete external drainage of bile. Studies were performed on male Wistar rats (n = 45). Controls consisted of animals subjected to sham surgery with preservation of physiological bile flow throughout the experiment.

Metabolic changes in rat brain histaminergic neurons during subhepatic cholestasis.

The aim of the present work was to assess metabolic changes in histaminergic neurons in the rat brain during subhepatic cholestasis. Studies were performed on male Wistar rats using quantitative histochemical methods. The results showed that in cholestasis, histaminergic neurons in the rat hypothalamus developed significant changes in succinate dehydrogenase, lactate dehydrogenase, and glucose-6-phosphate dehydrogenase activity, in NADH and NADPH, and in acid phosphatase and monoamine oxidase B.

[Structural and metabolic changes in the rat hypothalamic histaminergic neurons induced by the bile loss].

The aim of the study was the estimation of structural and metabolic changes in histaminergic neurons of rat hypothalamic E2 nucleus induced by total external bile drainage. The investigation was carried out on male Wistar rats (n=45). The control group comprised the sham-operated animals, in which the physiological bile drainage was preserved during the whole experimental period.

[Metabolic changes in rat brain histaminergic neurons in dynamics of subhepatic cholestasis].

The aim of the study was the estimation of metabolic changes in rat brain histaminergic neurons in dynamics of subhepatic cholestasis. The investigation was carried out in male Wistar rats using the quantitative histochemical methods. It was found that cholestasis induced significant changes in the activity of dehydrogenases of succinate, lactate, glucose-6-phosphate, NADH and NADPH, as well as of acid phosphatase and type B monoamine oxidase in hypothalamic histaminergic neurons.