[; CLINICAL CASE OF STAT3 GOF IMMUNE DYSREGULATION DISEASE, ALPS].

Dysregulation of the immune system occurs when the immune system cannot regulate normal control of inflammation, which leads to the most common severe inflammatory infections. Some of the manifestations of diseases of immune dysregulation are called diseases of increased function of STAT1 (GOF) and enhanced function of STAT3 (GOF). STAT stands for a kind of signal converter and transcription activator.