Publications by authors named "O U Orji"
N6 adenosine and C5 cytosine modification of mRNAs, tRNAs and rRNAs are regulated by the behaviour of distinct sets of writer, reader and eraser effector proteins which are conventionally considered to function independently. Here, we provide evidence of global cross-regulatory and functional interaction between the mA and mC RNA methylation systems. We first show that mA and mC effector protein transcripts are subject to reciprocal base modification supporting the existence of co-regulatory post-transcriptional feedback loops.
View Article and Find Full Text PDFArticle Synopsis
- - This study explores the impact of Bisphenol A (BPA), an endocrine disruptor known to affect male fertility, on the testicular mitochondria of male albino rats and tests the protective effects of seed oil (CMSO).
- - Six groups of rats were used, with varying doses of BPA and CMSO; the study measured mitochondrial enzyme activity, membrane potential, protein levels, and body weight post-exposure.
- - Results showed that BPA reduced key mitochondrial activities and rat body weight, but coadministration of CMSO helped restore these disrupted functions, suggesting CMSO could be a potential treatment for toxins like BPA.
Patients who are receiving carboplatin therapy for cancer often experience toxic side effects. This study examined the effects of lyophilized aqueous leaf extracts of F. capensis (LALEFC) on oxidative stress and inflammatory markers in albino rats with carboplatin-damaged livers.
View Article and Find Full Text PDFBackground Parkinson's disease (PD) is a chronic neurodegenerative disorder that significantly impacts patients' quality of life (QoL). Depression is a common comorbidity in patients with PD, potentially exacerbating QoL deterioration. This study aimed to assess the influence of depression on QoL in patients with PD at Ladoke Akintola University of Technology (LAUTECH), Ogbomoso, Nigeria.
View Article and Find Full Text PDFObjective: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical use. The present study was undertaken to examine whether leaf extract (DSLE) could block MTX nephrotoxic side effect in rats.
Materials And Methods: Animals were divided randomly into Control, Ethanol extract, MTX, and Extract + MTX groups.