Publications by authors named "O Tomkins"
Lymphoplasmacytic lymphoma (LPL) is a relatively rare form of indolent B-cell non-Hodgkin's lymphoma, termed Waldenström's macroglobulinaemia (WM) in the presence of an IgM paraprotein. Although traditionally treated with combination chemoimmunotherapy, the management is evolving in the era of targeted molecular therapies including Bruton's tyrosine kinase inhibitors (BTKi). However, intolerance and refractoriness to BTKi mean newer agents are required, and the prognosis of so-called quadruple-refractory patients is poor.
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- This review talks about how blood disorders can affect the nerves, and how it can be hard to diagnose these problems.
- New studies are helping to understand more about nerve damage in patients with certain blood conditions and some specific syndromes.
- The article also discusses the challenges doctors face in diagnosing and treating nerve issues caused by cancer treatments and blood diseases.
Investigation and Management of Immunoglobulin M- and Waldenström-Associated Peripheral Neuropathies.
Hematol Oncol Clin North Am
August 2023
Article Synopsis
- IgM-associated peripheral neuropathies (PN) are a diverse group of disorders linked to conditions like IgM monoclonal gammopathy of undetermined significance (MGUS) or Waldenström macroglobulinemia.
- Identifying the relationship between paraproteins and neuropathies is crucial for determining effective treatment strategies.
- The most common IgM-PN is Antimyelin-Associated-Glycoprotein neuropathy, but many cases have different underlying causes; treatment options include rituximab or chemotherapy, especially when functional impairment worsens.
Patients with haematological malignancies have a high risk of severe infection and death from SARS-CoV-2. In this prospective observational study, we investigated the impact of cancer type, disease activity, and treatment in 877 unvaccinated UK patients with SARS-CoV-2 infection and active haematological cancer. The primary end-point was all-cause mortality.
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