Publications by authors named "O Telnov"
: Determine TB-LAM is a urine-based point-of-care assay for diagnosis of tuberculosis (TB). : To assess the feasibility of using LAM to diagnose TB in adult HIV-positive patients in resource-limited settings. : We performed a multi-centric mixed-methods cross-sectional descriptive study in the Democratic Republic of Congo, Malawi, and Mozambique.
View Article and Find Full Text PDFWe present a case report describing outcomes in a 21 year old HIV-negative man who received treatment with bedaquiline. Due to error, dosage received comprised 4 pills of 100 mg every second day in the 60 days following the first two weeks of 4 pills of 100 mg every day. On detection, treatment was continued as per standard dosing of 200 mg given three times per week, with enhanced monitoring of ECG and liver function.
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- The Médecins Sans Frontières project in Uzbekistan has been treating multidrug-resistant tuberculosis (MDR-TB) in Karakalpakstan since 2003, facing high rates of treatment default, especially after scaling up in 2007.
- A retrospective analysis of patients treated between 2003 and 2008 revealed that 20% defaulted after an average of 6 months, with prior default, older age, and higher severity of resistance patterns as key factors.
- The findings highlight the need for enhanced patient and staff support alongside treatment scale-up, as well as the importance of successful initial treatment courses to reduce risks of default and mortality.
Multidrug-resistant tuberculosis (MDR-TB; resistance to at least rifampicin and isoniazid) is a global public health concern. In 2010–2011, Uzbekistan, in central Asia, conducted its first countrywide survey to determine the prevalence of MDR-TB among TB patients. The proportion of MDR-TB among new and previously treated TB patients throughout the country was measured and risk factors for MDR-TB explored.
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